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Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle.
Neelakantan H, Brightwell CR, Graber TG, Maroto R, Wang HL, McHardy SF, Papaconstantinou J, Fry CS, Watowich SJ. Neelakantan H, et al. Among authors: watowich sj. Biochem Pharmacol. 2019 May;163:481-492. doi: 10.1016/j.bcp.2019.02.008. Epub 2019 Feb 10. Biochem Pharmacol. 2019. PMID: 30753815 Free PMC article.
Late-life exercise mitigates skeletal muscle epigenetic aging.
Murach KA, Dimet-Wiley AL, Wen Y, Brightwell CR, Latham CM, Dungan CM, Fry CS, Watowich SJ. Murach KA, et al. Among authors: watowich sj. Aging Cell. 2022 Jan;21(1):e13527. doi: 10.1111/acel.13527. Epub 2021 Dec 21. Aging Cell. 2022. PMID: 34932867 Free PMC article.
Muscle-Specific Cellular and Molecular Adaptations to Late-Life Voluntary Concurrent Exercise.
Dungan CM, Brightwell CR, Wen Y, Zdunek CJ, Latham CM, Thomas NT, Zagzoog AM, Brightwell BD, VonLehmden GL, Keeble AR, Watowich SJ, Murach KA, Fry CS. Dungan CM, et al. Among authors: watowich sj. Function (Oxf). 2022 May 23;3(4):zqac027. doi: 10.1093/function/zqac027. eCollection 2022. Function (Oxf). 2022. PMID: 35774589 Free PMC article.
A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle.
Jones RG 3rd, Dimet-Wiley A, Haghani A, da Silva FM, Brightwell CR, Lim S, Khadgi S, Wen Y, Dungan CM, Brooke RT, Greene NP, Peterson CA, McCarthy JJ, Horvath S, Watowich SJ, Fry CS, Murach KA. Jones RG 3rd, et al. Among authors: watowich sj. J Physiol. 2023 Feb;601(4):763-782. doi: 10.1113/JP283836. Epub 2023 Jan 24. J Physiol. 2023. PMID: 36533424 Free PMC article.
61 results