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ASCT2 is a major contributor to serine uptake in cancer cells.
Conger KO, Chidley C, Ozgurses ME, Zhao H, Kim Y, Semina SE, Burns P, Rawat V, Lietuvninkas L, Sheldon R, Ben-Sahra I, Frasor J, Sorger PK, DeNicola GM, Coloff JL. Conger KO, et al. Among authors: sheldon r. Cell Rep. 2024 Aug 27;43(8):114552. doi: 10.1016/j.celrep.2024.114552. Epub 2024 Jul 27. Cell Rep. 2024. PMID: 39068660 Free PMC article.
ASCT2 is the primary serine transporter in cancer cells.
Conger KO, Chidley C, Ozgurses ME, Zhao H, Kim Y, Semina SE, Burns P, Rawat V, Sheldon R, Ben-Sahra I, Frasor J, Sorger PK, DeNicola GM, Coloff JL. Conger KO, et al. Among authors: sheldon r. bioRxiv [Preprint]. 2023 Oct 11:2023.10.09.561530. doi: 10.1101/2023.10.09.561530. bioRxiv. 2023. PMID: 37873453 Free PMC article. Preprint.
Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking.
Sokol KH, Lee CJ, Rogers TJ, Waldhart A, Ellis AE, Madireddy S, Daniels SR, House RRJ, Ye X, Olesnavich M, Johnson A, Furness BR, Sheldon RD, Lien EC. Sokol KH, et al. Among authors: sheldon rd. Cell Chem Biol. 2024 Oct 14:S2451-9456(24)00404-5. doi: 10.1016/j.chembiol.2024.09.008. Online ahead of print. Cell Chem Biol. 2024. PMID: 39442523 Free article.
Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking.
Sokol KH, Lee CJ, Rogers TJ, Waldhart A, Ellis AE, Madireddy S, Daniels SR, Ye X, Olesnavich M, Johnson A, Furness BR, Sheldon RD, Lien EC. Sokol KH, et al. Among authors: sheldon rd. bioRxiv [Preprint]. 2024 May 9:2024.05.06.592780. doi: 10.1101/2024.05.06.592780. bioRxiv. 2024. Update in: Cell Chem Biol. 2024 Oct 14:S2451-9456(24)00404-5. doi: 10.1016/j.chembiol.2024.09.008 PMID: 38766165 Free PMC article. Updated. Preprint.
Acod1 Expression in Cancer Cells Promotes Immune Evasion through the Generation of Inhibitory Peptides.
Schofield JH, Longo J, Sheldon RD, Albano E, Hawk MA, Murphy S, Duong L, Rahmy S, Lu X, Jones RG, Schafer ZT. Schofield JH, et al. bioRxiv [Preprint]. 2023 Sep 17:2023.09.14.557799. doi: 10.1101/2023.09.14.557799. bioRxiv. 2023. Update in: Cell Rep. 2024 Apr 23;43(4):113984. doi: 10.1016/j.celrep.2024.113984 PMID: 37745450 Free PMC article. Updated. Preprint.
NF1 deficiency drives metabolic reprogramming in ER+ breast cancer.
House RRJ, Tovar EA, Redlon LN, Essenburg CJ, Dischinger PS, Ellis AE, Beddows I, Sheldon RD, Lien EC, Graveel CR, Steensma MR. House RRJ, et al. Among authors: sheldon rd. Mol Metab. 2024 Feb;80:101876. doi: 10.1016/j.molmet.2024.101876. Epub 2024 Jan 10. Mol Metab. 2024. PMID: 38216123 Free PMC article.
NRF2-dependent regulation of the prostacyclin receptor PTGIR drives CD8 T cell exhaustion.
Dahabieh MS, DeCamp LM, Oswald BM, Kitchen-Goosen SM, Fu Z, Vos M, Compton SE, Longo J, Williams KS, Ellis AE, Johnson A, Sodiya I, Vincent M, Lee H, Sheldon RD, Krawczyk CM, Yao C, Wu T, Jones RG. Dahabieh MS, et al. bioRxiv [Preprint]. 2024 Jun 28:2024.06.23.600279. doi: 10.1101/2024.06.23.600279. bioRxiv. 2024. PMID: 38979360 Free PMC article. Preprint.
13C metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8+ T cells.
Ma EH, Dahabieh MS, DeCamp LM, Kaymak I, Kitchen-Goosen SM, Roy DG, Verway MJ, Johnson RM, Samborska B, Scullion CA, Steadman M, Vos M, Roddy TP, Krawczyk CM, Williams KS, Sheldon RD, Jones RG. Ma EH, et al. bioRxiv [Preprint]. 2023 Jun 11:2023.06.09.544407. doi: 10.1101/2023.06.09.544407. bioRxiv. 2023. Update in: Sci Adv. 2024 May 31;10(22):eadj1431. doi: 10.1126/sciadv.adj1431 PMID: 37333111 Free PMC article. Updated. Preprint.
696 results