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Page 1
RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability.
Jalan M, Sharma A, Pei X, Weinhold N, Buechelmaier ES, Zhu Y, Ahmed-Seghir S, Ratnakumar A, Di Bona M, McDermott N, Gomez-Aguilar J, Anderson KS, Ng CKY, Selenica P, Bakhoum SF, Reis-Filho JS, Riaz N, Powell SN. Jalan M, et al. Among authors: bakhoum sf. Nat Commun. 2024 Sep 5;15(1):7776. doi: 10.1038/s41467-024-51784-x. Nat Commun. 2024. PMID: 39237529 Free PMC article.
Micronuclear collapse from oxidative damage.
Di Bona M, Chen Y, Agustinus AS, Mazzagatti A, Duran MA, Deyell M, Bronder D, Hickling J, Hong C, Scipioni L, Tedeschi G, Martin S, Li J, Ruzgaitė A, Riaz N, Shah P, D'Souza EK, Brodtman DZ, Sidoli S, Diplas B, Jalan M, Lee NY, Ordureau A, Izar B, Laughney AM, Powell S, Gratton E, Santaguida S, Maciejowski J, Ly P, Jeitner TM, Bakhoum SF. Di Bona M, et al. Among authors: bakhoum sf. Science. 2024 Aug 30;385(6712):eadj8691. doi: 10.1126/science.adj8691. Epub 2024 Aug 30. Science. 2024. PMID: 39208110
A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements.
Martin S, Scorzoni S, Cordone S, Mazzagatti A, Beznoussenko GV, Gunn AL, Di Bona M, Eliezer Y, Leor G, Ben-Yishay T, Loffreda A, Cancila V, Rainone MC, Ippolito MR, Martis V, Bedin F, Garrè M, Vaites LP, Vasapolli P, Polo S, Parazzoli D, Tripodo C, Mironov AA, Cuomo A, Ben-David U, Bakhoum SF, Hatch EM, Ly P, Santaguida S. Martin S, et al. Among authors: bakhoum sf. Science. 2024 Aug 30;385(6712):eadj7446. doi: 10.1126/science.adj7446. Epub 2024 Aug 30. Science. 2024. PMID: 39208097
Chromosomal instability as a driver of cancer progression.
Chen X, Agustinus AS, Li J, DiBona M, Bakhoum SF. Chen X, et al. Among authors: bakhoum sf. Nat Rev Genet. 2024 Jul 29. doi: 10.1038/s41576-024-00761-7. Online ahead of print. Nat Rev Genet. 2024. PMID: 39075192 Review.
Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer.
McPherson A, Vázquez-García I, Myers MA, Zatzman M, Al-Rawi D, Weiner A, Freeman S, Mohibullah N, Satas G, Williams MJ, Ceglia N, Zhang AW, Li J, Lim JLP, Wu M, Choi S, Havasov E, Grewal D, Shi H, Kim M, Schwarz R, Kaufmann T, Dinh KN, Uhlitz F, Tran J, Wu Y, Patel R, Ramakrishnan S, Kim D, Clarke J, Green H, Ali E, DiBona M, Varice N, Kundra R, Broach V, Gardner GJ, Roche KL, Sonoda Y, Zivanovic O, Kim SH, Grisham RN, Liu YL, Viale A, Rusk N, Lakhman Y, Ellenson LH, Tavaré S, Aparicio S, Chi DS, Aghajanian C, Abu-Rustum NR, Friedman CF, Zamarin D, Weigelt B, Bakhoum SF, Shah SP. McPherson A, et al. Among authors: bakhoum sf. bioRxiv [Preprint]. 2024 Jul 15:2024.07.11.602772. doi: 10.1101/2024.07.11.602772. bioRxiv. 2024. PMID: 39071261 Free PMC article. Preprint.
Targeting chromosomal instability in patients with cancer.
Al-Rawi DH, Lettera E, Li J, DiBona M, Bakhoum SF. Al-Rawi DH, et al. Among authors: bakhoum sf. Nat Rev Clin Oncol. 2024 Sep;21(9):645-659. doi: 10.1038/s41571-024-00923-w. Epub 2024 Jul 11. Nat Rev Clin Oncol. 2024. PMID: 38992122 Review.
Validation of Patient-Reported Outcomes in Patients With Nonmetastatic Breast Cancer Receiving Comprehensive Nodal Irradiation in the RadComp Trial.
Hahn EA, Pugh SL, Lu HL, Vela AM, Gillespie EF, Nichols EM, Wright JL, MacDonald SM, Cahlon O, Baas C, Braunstein LZ, Fang LC, Freedman GM, Jimenez RB, Kesslering CM, Mishra MV, Mutter RW, Ohri N, Rosen LR, Urbanic JJ, Jagsi R, Mitchell SA, Bekelman JE, Cella D; Study Group Investigators:. Hahn EA, et al. Int J Radiat Oncol Biol Phys. 2024 Sep 1;120(1):149-161. doi: 10.1016/j.ijrobp.2024.03.020. Epub 2024 May 13. Int J Radiat Oncol Biol Phys. 2024. PMID: 38739047 Free PMC article. Clinical Trial.
Molecular and Clinical Determinants of Acquired Resistance and Treatment Duration for Targeted Therapies in Colorectal Cancer.
Harrold E, Keane F, Walch H, Chou JF, Sinopoli J, Palladino S, Al-Rawi DH, Chadalavada K, Manca P, Chalasani S, Yang J, Cercek A, Shia J, Capanu M, Bakhoum SF, Schultz N, Chatila WK, Yaeger R. Harrold E, et al. Among authors: bakhoum sf. Clin Cancer Res. 2024 Jun 14;30(12):2672-2683. doi: 10.1158/1078-0432.CCR-23-4005. Clin Cancer Res. 2024. PMID: 38502113 Free PMC article.
Intratumoral TREX1 Induction Promotes Immune Evasion by Limiting Type I IFN.
Toufektchan E, Dananberg A, Striepen J, Hickling JH, Shim A, Chen Y, Nichols A, Duran Paez MA, Mohr L, Bakhoum SF, Maciejowski J. Toufektchan E, et al. Among authors: bakhoum sf. Cancer Immunol Res. 2024 Jun 4;12(6):673-686. doi: 10.1158/2326-6066.CIR-23-1093. Cancer Immunol Res. 2024. PMID: 38408184 Free PMC article.
81 results