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Page 1
Template-assisted covalent modification underlies activity of covalent molecular glues.
Li YD, Ma MW, Hassan MM, Hunkeler M, Teng M, Puvar K, Rutter JC, Lumpkin RJ, Sandoval B, Jin CY, Schmoker AM, Ficarro SB, Cheong H, Metivier RJ, Wang MY, Xu S, Byun WS, Groendyke BJ, You I, Sigua LH, Tavares I, Zou C, Tsai JM, Park PMC, Yoon H, Majewski FC, Sperling HT, Marto JA, Qi J, Nowak RP, Donovan KA, Słabicki M, Gray NS, Fischer ES, Ebert BL. Li YD, et al. Among authors: byun ws. Nat Chem Biol. 2024 Dec;20(12):1640-1649. doi: 10.1038/s41589-024-01668-4. Epub 2024 Jul 29. Nat Chem Biol. 2024. PMID: 39075252 Free PMC article.
Discovery of electrophilic degraders that exploit SNAr chemistry.
Zhuang Z, Byun WS, Kozicka Z, Dwyer BG, Donovan KA, Jiang Z, Jones HM, Abeja DM, Nix MN, Zhong J, Słabicki M, Fischer ES, Ebert BL, Gray NS. Zhuang Z, et al. Among authors: byun ws. bioRxiv [Preprint]. 2024 Sep 27:2024.09.25.615094. doi: 10.1101/2024.09.25.615094. bioRxiv. 2024. PMID: 39386645 Free PMC article. Preprint.
Targeted and Logical Discovery of Piperazic Acid-Bearing Natural Products Based on Genomic and Spectroscopic Signatures.
Shin D, Byun WS, Kang S, Kang I, Bae ES, An JS, Im JH, Park J, Kim E, Ko K, Hwang S, Lee H, Kwon Y, Ko YJ, Hong S, Nam SJ, Kim SB, Fenical W, Yoon YJ, Cho JC, Lee SK, Oh DC. Shin D, et al. Among authors: byun ws. J Am Chem Soc. 2023 Sep 13;145(36):19676-19690. doi: 10.1021/jacs.3c04699. Epub 2023 Aug 29. J Am Chem Soc. 2023. PMID: 37642383
Structure-Activity Relationship of Truncated 2,8-Disubstituted-Adenosine Derivatives as Dual A2A/A3 Adenosine Receptor Antagonists and Their Cancer Immunotherapeutic Activity.
Kim G, Hou X, Byun WS, Kim G, Jarhad DB, Lee G, Hyun YE, Yu J, Lee CS, Qu S, Warnick E, Gao ZG, Kim JY, Ji S, Shin H, Choi JR, Jacobson KA, Lee HW, Lee SK, Jeong LS. Kim G, et al. Among authors: byun ws. J Med Chem. 2023 Sep 14;66(17):12249-12265. doi: 10.1021/acs.jmedchem.3c00806. Epub 2023 Aug 21. J Med Chem. 2023. PMID: 37603705 Free PMC article.
Activating p53Y220C with a Mutant-Specific Small Molecule.
Zhu X, Byun WS, Pieńkowska DE, Nguyen KT, Gerhartz J, Geng Q, Qiu T, Zhong J, Jiang Z, Wang M, Sarott RC, Hinshaw SM, Zhang T, Attardi LD, Nowak RP, Gray NS. Zhu X, et al. Among authors: byun ws. bioRxiv [Preprint]. 2024 Oct 28:2024.10.23.619961. doi: 10.1101/2024.10.23.619961. bioRxiv. 2024. PMID: 39554093 Free PMC article. Preprint.
Exploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues.
Hassan MM, Li YD, Ma MW, Teng M, Byun WS, Puvar K, Lumpkin R, Sandoval B, Rutter JC, Jin CY, Wang MY, Xu S, Schmoker AM, Cheong H, Groendyke BJ, Qi J, Fischer ES, Ebert BL, Gray NS. Hassan MM, et al. Among authors: byun ws. Eur J Med Chem. 2024 Dec 5;279:116904. doi: 10.1016/j.ejmech.2024.116904. Epub 2024 Sep 24. Eur J Med Chem. 2024. PMID: 39341093 Free article.
50 results