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Page 1
Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy.
Bumpers QA, Pipal RW, Benz-Weeden AM, Brewster JT 2nd, Cook A, Crooks AL, Cruz C, Dwulet NC, Gaudino JJ, Golec D, Harrison JA, Hartley DP, Hassanien SH, Hicken EJ, Kahn D, Laird ER, Lemieux C, Lewandowski N, McCown J, McDonald MG, McNulty O, Mou TC, Nguyen P, Oko L, Opie LP, Otten J, Peck SC, Polites VC, Randall SD, Rosen RZ, Savechenkov P, Simpson H, Singh A, Sparks D, Wickersham K, Wollenberg L, Wong CE, Wong J, Wu WI, Elsayed MSA, Hinklin RJ, Tang TP. Bumpers QA, et al. Among authors: golec d. J Med Chem. 2024 Aug 22;67(16):14466-14477. doi: 10.1021/acs.jmedchem.4c01232. Epub 2024 Aug 1. J Med Chem. 2024. PMID: 39088797
Eosinophil trafficking in allergen-mediated pulmonary inflammation relies on IL-13-driven CCL-11 and CCL-24 production by tissue fibroblasts and myeloid cells.
Gazzinelli-Guimaraes PH, Golec DP, Karmele EP, Sciurba J, Bara-Garcia P, Hill T, Kang B, Bennuru S, Schwartzberg PL, Nutman TB. Gazzinelli-Guimaraes PH, et al. Among authors: golec dp. J Allergy Clin Immunol Glob. 2023 Jun 26;2(4):100131. doi: 10.1016/j.jacig.2023.100131. eCollection 2023 Nov. J Allergy Clin Immunol Glob. 2023. PMID: 37781651 Free PMC article.
TCR-independent CD137 (4-1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiation.
Pichler AC, Carrié N, Cuisinier M, Ghazali S, Voisin A, Axisa PP, Tosolini M, Mazzotti C, Golec DP, Maheo S, do Souto L, Ekren R, Blanquart E, Lemaitre L, Feliu V, Joubert MV, Cannons JL, Guillerey C, Avet-Loiseau H, Watts TH, Salomon BL, Joffre O, Grinberg-Bleyer Y, Schwartzberg PL, Lucca LE, Martinet L. Pichler AC, et al. Among authors: golec dp. Immunity. 2023 Jul 11;56(7):1631-1648.e10. doi: 10.1016/j.immuni.2023.06.007. Epub 2023 Jun 30. Immunity. 2023. PMID: 37392737 Free PMC article.
Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis.
Ogishi M, Yang R, Rodriguez R, Golec DP, Martin E, Philippot Q, Bohlen J, Pelham SJ, Arias AA, Khan T, Ata M, Al Ali F, Rozenberg F, Kong XF, Chrabieh M, Laine C, Lei WT, Han JE, Seeleuthner Y, Kaul Z, Jouanguy E, Béziat V, Youssefian L, Vahidnezhad H, Rao VK, Neven B, Fieschi C, Mansouri D, Shahrooei M, Pekcan S, Alkan G, Emiroğlu M, Tokgöz H, Uitto J, Hauck F, Bustamante J, Abel L, Keles S, Parvaneh N, Marr N, Schwartzberg PL, Latour S, Casanova JL, Boisson-Dupuis S. Ogishi M, et al. Among authors: golec dp. J Exp Med. 2023 Jan 2;220(1):e20220484. doi: 10.1084/jem.20220484. Epub 2022 Nov 3. J Exp Med. 2023. PMID: 36326697 Free PMC article.
A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells.
Johansen KH, Golec DP, Huang B, Park C, Thomsen JH, Preite S, Cannons JL, Garçon F, Schrom EC, Courrèges CJF, Veres TZ, Harrison J, Nus M, Phelan JD, Bergmeier W, Kehrl JH, Okkenhaug K, Schwartzberg PL. Johansen KH, et al. Among authors: golec dp. Sci Signal. 2022 Jul 19;15(743):eabl9169. doi: 10.1126/scisignal.abl9169. Epub 2022 Jul 19. Sci Signal. 2022. PMID: 35857633 Free PMC article.
γδ Thymocyte Maturation and Emigration in Adult Mice.
Joannou K, Golec DP, Wang H, Henao-Caviedes LM, May JF, Kelly RG, Chan R, Jameson SC, Baldwin TA. Joannou K, et al. Among authors: golec dp. J Immunol. 2022 May 1;208(9):2131-2140. doi: 10.4049/jimmunol.2100360. Epub 2022 Apr 8. J Immunol. 2022. PMID: 35396221
PI3K in T Cell Adhesion and Trafficking.
Johansen KH, Golec DP, Thomsen JH, Schwartzberg PL, Okkenhaug K. Johansen KH, et al. Among authors: golec dp. Front Immunol. 2021 Aug 6;12:708908. doi: 10.3389/fimmu.2021.708908. eCollection 2021. Front Immunol. 2021. PMID: 34421914 Free PMC article. Review.
15 results