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A phase I trial of LHC165 single agent and in combination with spartalizumab in patients with advanced solid malignancies.
Curigliano G, Jimenez MM, Shimizu T, Keam B, Meric-Bernstam F, Rutten A, Glaspy J, Schuler PJ, Parikh NS, Ising M, Hassounah N, Wu J, Leyk M, Chen X, Burks H, Chaudhury A, Otero J, Cabanas EG. Curigliano G, et al. Among authors: cabanas eg. ESMO Open. 2024 Aug;9(8):103643. doi: 10.1016/j.esmoop.2024.103643. Epub 2024 Jul 31. ESMO Open. 2024. PMID: 39088985 Free PMC article. Clinical Trial.
Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein.
Kroenke MA, Starcevic Manning M, Zuch de Zafra CL, Zhang X, Cook KD, Archer M, Lolkema MP, Wang J, Hoofring S, Saini G, Aeffner F, Ahern E, Cabanas EG, Govindan R, Hui M, Gupta S, Mytych DT. Kroenke MA, et al. Among authors: cabanas eg. Front Immunol. 2024 Jan 26;15:1345473. doi: 10.3389/fimmu.2024.1345473. eCollection 2024. Front Immunol. 2024. PMID: 38343535 Free PMC article.
Corrigendum: Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein.
Kroenke MA, Manning MS, Zuch de Zafra CL, Zhang X, Cook KD, Archer M, Lolkema MP, Wang J, Hoofring S, Saini G, Aeffner F, Ahern E, Cabanas EG, Govindan R, Hui M, Gupta S, Mytych DT. Kroenke MA, et al. Among authors: cabanas eg. Front Immunol. 2024 Jun 20;15:1441999. doi: 10.3389/fimmu.2024.1441999. eCollection 2024. Front Immunol. 2024. PMID: 38966638 Free PMC article.