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Page 1
4-(3-Phenylsulfonylindol-2-yl)-1-(pyridin-2-yl)piperazinyl-methanones as Potent Inhibitors of both SARS-CoV-2 and HCoV-OC43 Viruses.
Puxeddu M, Donalisio M, Bugert JJ, Corona A, Cocomazzi P, Milani M, Hucke F, Arduino I, Esposito F, Moretti P, Ortore MG, Nalli M, Manetto S, Mazzoccanti G, Bigogno C, Dondio G, Sciò P, Coluccia A, Fracella M, Antonelli G, Lembo D, Tramontano E, Silvestri R, Mastrangelo E, La Regina G. Puxeddu M, et al. Among authors: nalli m. ACS Infect Dis. 2024 Sep 13;10(9):3158-3175. doi: 10.1021/acsinfecdis.4c00108. Epub 2024 Aug 3. ACS Infect Dis. 2024. PMID: 39096289
Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the β-Catenin Armadillo Repeats Domain as an Anticancer Agent.
Nalli M, Di Magno L, Wen Y, Liu X, D'Ambrosio M, Puxeddu M, Parisi A, Sebastiani J, Sorato A, Coluccia A, Ripa S, Di Pastena F, Capelli D, Montanari R, Masci D, Urbani A, Naro C, Sette C, Orlando V, D'Angelo S, Biagioni S, Bigogno C, Dondio G, Pastore A, Stornaiuolo M, Canettieri G, Liu T, Silvestri R, La Regina G. Nalli M, et al. ACS Pharmacol Transl Sci. 2023 Jul 3;6(7):1087-1103. doi: 10.1021/acsptsci.3c00092. eCollection 2023 Jul 14. ACS Pharmacol Transl Sci. 2023. PMID: 37470018 Free PMC article.
Development of N-(4-(1H-Imidazol-1-yl)phenyl)-4-chlorobenzenesulfonamide, a Novel Potent Inhibitor of β-Catenin with Enhanced Antitumor Activity and Metabolic Stability.
Puxeddu M, Ling L, Ripa S, D'Ambrosio M, Nalli M, Parisi A, Sciò P, Coluccia A, Granese A, Santelli M, Masci D, Cuřínová P, Naro C, Sette C, Pastore A, Stornaiuolo M, Bigogno C, Dondio G, Di Magno L, Canettieri G, Liu T, Silvestri R, La Regina G. Puxeddu M, et al. Among authors: nalli m. J Med Chem. 2024 Nov 28;67(22):20298-20314. doi: 10.1021/acs.jmedchem.4c01708. Epub 2024 Nov 7. J Med Chem. 2024. PMID: 39508273
4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells.
Masci D, Puxeddu M, Di Magno L, D'Ambrosio M, Parisi A, Nalli M, Bai R, Coluccia A, Sciò P, Orlando V, D'Angelo S, Biagioni S, Urbani A, Hamel E, Nocentini A, Filiberti S, Turati M, Ronca R, Kopecka J, Riganti C, Fionda C, Bordone R, Della Rocca G, Canettieri G, Supuran CT, Silvestri R, La Regina G. Masci D, et al. Among authors: nalli m. J Med Chem. 2023 Nov 9;66(21):14824-14842. doi: 10.1021/acs.jmedchem.3c01424. Epub 2023 Oct 30. J Med Chem. 2023. PMID: 37902628 Free PMC article.
Structure-activity relationship of dibenzylideneacetone analogs against the neglected disease pathogen, Trypanosoma brucei.
Francisco KR, Monti L, Yang W, Park H, Liu LJ, Watkins K, Amarasinghe DK, Nalli M, Roberto Polaquini C, Regasini LO, Eduardo Miller Crotti A, Silvestri R, Guidi Magalhães L, Caffrey CR. Francisco KR, et al. Among authors: nalli m. Bioorg Med Chem Lett. 2023 Feb 1;81:129123. doi: 10.1016/j.bmcl.2023.129123. Epub 2023 Jan 3. Bioorg Med Chem Lett. 2023. PMID: 36608774 Free PMC article.
RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo.
Sebastiani J, Puxeddu M, Nalli M, Bai R, Altieri L, Rovella P, Gaudio E, Trisciuoglio D, Spriano F, Lavia P, Fionda C, Masci D, Urbani A, Bigogno C, Dondio G, Hamel E, Bertoni F, Silvestri R, La Regina G. Sebastiani J, et al. Among authors: nalli m. Eur J Med Chem. 2023 Jan 15;246:114997. doi: 10.1016/j.ejmech.2022.114997. Epub 2022 Dec 5. Eur J Med Chem. 2023. PMID: 36502578
Emerging Direct Targeting β-Catenin Agents.
Nalli M, Masci D, Urbani A, La Regina G, Silvestri R. Nalli M, et al. Molecules. 2022 Nov 10;27(22):7735. doi: 10.3390/molecules27227735. Molecules. 2022. PMID: 36431838 Free PMC article. Review.
Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor.
Puxeddu M, Wu J, Bai R, D'Ambrosio M, Nalli M, Coluccia A, Manetto S, Ciogli A, Masci D, Urbani A, Fionda C, Coni S, Bordone R, Canettieri G, Bigogno C, Dondio G, Hamel E, Liu T, Silvestri R, La Regina G. Puxeddu M, et al. Among authors: nalli m. J Med Chem. 2022 Dec 8;65(23):15805-15818. doi: 10.1021/acs.jmedchem.2c01457. Epub 2022 Nov 17. J Med Chem. 2022. PMID: 36395526 Free PMC article.
62 results