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Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer's disease.
Jury-Garfe N, Redding-Ochoa J, You Y, Martínez P, Karahan H, Chimal-Juárez E, Johnson TS, Zhang J, Resnick S, Kim J, Troncoso JC, Lasagna-Reeves CA. Jury-Garfe N, et al. Among authors: martinez p. Acta Neuropathol. 2024 Aug 5;148(1):15. doi: 10.1007/s00401-024-02775-1. Acta Neuropathol. 2024. PMID: 39102080 Free PMC article.
The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer's disease.
Moutinho M, Puntambekar SS, Tsai AP, Coronel I, Lin PB, Casali BT, Martinez P, Oblak AL, Lasagna-Reeves CA, Lamb BT, Landreth GE. Moutinho M, et al. Among authors: martinez p. Sci Transl Med. 2022 Mar 23;14(637):eabl7634. doi: 10.1126/scitranslmed.abl7634. Epub 2022 Mar 23. Sci Transl Med. 2022. PMID: 35320002 Free PMC article.
Activated endothelial cells induce a distinct type of astrocytic reactivity.
Taylor X, Cisternas P, Jury N, Martinez P, Huang X, You Y, Redding-Ochoa J, Vidal R, Zhang J, Troncoso J, Lasagna-Reeves CA. Taylor X, et al. Among authors: martinez p. Commun Biol. 2022 Mar 29;5(1):282. doi: 10.1038/s42003-022-03237-8. Commun Biol. 2022. PMID: 35351973 Free PMC article.
TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation.
Moutinho M, Coronel I, Tsai AP, Di Prisco GV, Pennington T, Atwood BK, Puntambekar SS, Smith DC, Martinez P, Han S, Lee Y, Lasagna-Reeves CA, Lamb BT, Bissel SJ, Nho K, Landreth GE. Moutinho M, et al. Among authors: martinez p. Genome Med. 2023 Feb 20;15(1):11. doi: 10.1186/s13073-023-01160-z. Genome Med. 2023. PMID: 36805764 Free PMC article.
Enhanced microglial dynamics and paucity of tau seeding in the amyloid plaque microenvironment contributes to cognitive resilience in Alzheimer's disease.
Jury-Garfe N, You Y, Martínez P, Redding-Ochoa J, Karahan H, Johnson TS, Zhang J, Kim J, Troncoso JC, Lasagna-Reeves CA. Jury-Garfe N, et al. Among authors: martinez p. bioRxiv [Preprint]. 2023 Jul 28:2023.07.27.550884. doi: 10.1101/2023.07.27.550884. bioRxiv. 2023. Update in: Acta Neuropathol. 2024 Aug 5;148(1):15. doi: 10.1007/s00401-024-02775-1 PMID: 37546928 Free PMC article. Updated. Preprint.
Network analysis identifies strain-dependent response to tau and tau seeding-associated genes.
Acri DJ, You Y, Tate MD, Karahan H, Martinez P, McCord B, Sharify AD, John S, Kim B, Dabin LC, Philtjens S, Wijeratne HRS, McCray TJ, Smith DC, Bissel SJ, Lamb BT, Lasagna-Reeves CA, Kim J. Acri DJ, et al. Among authors: martinez p. J Exp Med. 2023 Nov 6;220(11):e20230180. doi: 10.1084/jem.20230180. Epub 2023 Aug 22. J Exp Med. 2023. PMID: 37606887 Free PMC article.
Therapeutic targeting of immunometabolism in Alzheimer's disease reveals a critical reliance on Hexokinase 2 dosage on microglial activation and disease progression.
Codocedo JF, Mera-Reina C, Lin PB, Puntambekar SS, Casali BT, Jury N, Martinez P, Lasagna-Reeves CA, Landreth GE. Codocedo JF, et al. Among authors: martinez p. bioRxiv [Preprint]. 2023 Nov 15:2023.11.11.566270. doi: 10.1101/2023.11.11.566270. bioRxiv. 2023. Update in: Cell Rep. 2024 Jul 23;43(7):114488. doi: 10.1016/j.celrep.2024.114488 PMID: 38014106 Free PMC article. Updated. Preprint.
Therapeutic targeting of immunometabolism reveals a critical reliance on hexokinase 2 dosage for microglial activation and Alzheimer's progression.
Codocedo JF, Mera-Reina C, Bor-Chian Lin P, Fallen PB, Puntambekar SS, Casali BT, Jury-Garfe N, Martinez P, Lasagna-Reeves CA, Landreth GE. Codocedo JF, et al. Among authors: martinez p. Cell Rep. 2024 Jul 23;43(7):114488. doi: 10.1016/j.celrep.2024.114488. Epub 2024 Jul 13. Cell Rep. 2024. PMID: 39002124 Free PMC article.
2,055 results