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Expression of the αVβ3 integrin affects prostate cancer sEV cargo and density and promotes sEV pro-tumorigenic activity in vivo through a GPI-anchored receptor, NgR2.
Verrillo CE, Quaglia F, Shields CD, Lin S, Kossenkov AV, Tang HY, Speicher D, Naranjo NM, Testa A, Kelly WK, Liu Q, Leiby B, Musante L, Sossey-Alaoui K, Dogra N, Chen TY, Altieri DC, Languino LR. Verrillo CE, et al. Among authors: altieri dc. J Extracell Vesicles. 2024 Aug;13(8):e12482. doi: 10.1002/jev2.12482. J Extracell Vesicles. 2024. PMID: 39105261 Free PMC article.
The NOGO receptor NgR2, a novel αVβ3 integrin effector, induces neuroendocrine differentiation in prostate cancer.
Quaglia F, Krishn SR, Sossey-Alaoui K, Rana PS, Pluskota E, Park PH, Shields CD, Lin S, McCue P, Kossenkov AV, Wang Y, Goodrich DW, Ku SY, Beltran H, Kelly WK, Corey E, Klose M, Bandtlow C, Liu Q, Altieri DC, Plow EF, Languino LR. Quaglia F, et al. Among authors: altieri dc. Sci Rep. 2022 Nov 7;12(1):18879. doi: 10.1038/s41598-022-21711-5. Sci Rep. 2022. PMID: 36344556 Free PMC article.
Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression.
Yeon M, Bertolini I, Agarwal E, Ghosh JC, Tang HY, Speicher DW, Keeney F, Sossey-Alaoui K, Pluskota E, Bialkowska K, Plow EF, Languino LR, Skordalakes E, Caino MC, Altieri DC. Yeon M, et al. Among authors: altieri dc. J Biol Chem. 2023 Jun;299(6):104774. doi: 10.1016/j.jbc.2023.104774. Epub 2023 May 2. J Biol Chem. 2023. PMID: 37142218 Free PMC article.
Targeting the αVβ3/NgR2 pathway in neuroendocrine prostate cancer.
Testa A, Quaglia F, Naranjo NM, Verrillo CE, Shields CD, Lin S, Pickles MW, Hamza DF, Von Schalscha T, Cheresh DA, Leiby B, Liu Q, Ding J, Kelly WK, Hooper DC, Corey E, Plow EF, Altieri DC, Languino LR. Testa A, et al. Among authors: altieri dc. Matrix Biol. 2023 Dec;124:49-62. doi: 10.1016/j.matbio.2023.11.003. Epub 2023 Nov 11. Matrix Biol. 2023. PMID: 37956856 Free PMC article.
Role of Kindlin 2 in prostate cancer.
Bialkowska K, El Khalki L, Rana PS, Wang W, Lindner DJ, Parker Y, Languino LR, Altieri DC, Pluskota E, Sossey-Alaoui K, Plow EF. Bialkowska K, et al. Among authors: altieri dc. Sci Rep. 2024 Aug 27;14(1):19809. doi: 10.1038/s41598-024-70202-2. Sci Rep. 2024. PMID: 39191802 Free PMC article.
Parkin activates innate immunity and promotes antitumor immune responses.
Perego M, Yeon M, Agarwal E, Milcarek AT, Bertolini I, Camisaschi C, Ghosh JC, Tang HY, Grandvaux N, Ruscetti M, Kossenkov AV, Preston-Alp S, Tempera I, Auslander N, Altieri DC. Perego M, et al. Among authors: altieri dc. J Clin Invest. 2024 Aug 30;134(22):e180983. doi: 10.1172/JCI180983. J Clin Invest. 2024. PMID: 39213189 Free PMC article.
267 results