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Page 1
Nanoscale tools to selectively destroy cancer cells.
Boudreault PL, Arseneault M, Otis F, Voyer N. Boudreault PL, et al. Chem Commun (Camb). 2008 May 14;(18):2118-20. doi: 10.1039/b800528a. Epub 2008 Apr 7. Chem Commun (Camb). 2008. PMID: 18438487
A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice.
Shapira T, Monreal IA, Dion SP, Jager M, Désilets A, Olmstead AD, Vandal T, Buchholz DW, Imbiakha B, Gao G, Chin A, Rees WD, Steiner T, Nabi IR, Marsault E, Sahler J, August A, Van de Walle G, Whittaker GR, Boudreault PL, Aguilar HC, Leduc R, Jean F. Shapira T, et al. Among authors: boudreault pl. bioRxiv [Preprint]. 2021 May 4:2021.05.03.442520. doi: 10.1101/2021.05.03.442520. bioRxiv. 2021. PMID: 33972944 Free PMC article. Preprint.
Modulation of the Passive Permeability of Semipeptidic Macrocycles: N- and C-Methylations Fine-Tune Conformation and Properties.
Comeau C, Ries B, Stadelmann T, Tremblay J, Poulet S, Fröhlich U, Côté J, Boudreault PL, Derbali RM, Sarret P, Grandbois M, Leclair G, Riniker S, Marsault É. Comeau C, et al. Among authors: boudreault pl. J Med Chem. 2021 May 13;64(9):5365-5383. doi: 10.1021/acs.jmedchem.0c02036. Epub 2021 Mar 22. J Med Chem. 2021. PMID: 33750117
Pharmacodynamic and pharmacokinetic profiles of a neurotensin receptor type 2 (NTS2) analgesic macrocyclic analog.
Chartier M, Desgagné M, Sousbie M, Rumsby C, Chevillard L, Théroux L, Haroune L, Côté J, Longpré JM, Boudreault PL, Marsault É, Sarret P. Chartier M, et al. Among authors: boudreault pl. Biomed Pharmacother. 2021 Sep;141:111861. doi: 10.1016/j.biopha.2021.111861. Epub 2021 Jul 3. Biomed Pharmacother. 2021. PMID: 34229249 Free article.
Size-Reduced Macrocyclic Analogues of [Pyr1]-apelin-13 Showing Negative Gα12 Bias Still Produce Prolonged Cardiac Effects.
Tran K, Sainsily X, Côté J, Coquerel D, Couvineau P, Saibi S, Haroune L, Besserer-Offroy É, Flynn-Robitaille J, Resua Rojas M, Murza A, Longpré JM, Auger-Messier M, Lesur O, Bouvier M, Marsault É, Boudreault PL, Sarret P. Tran K, et al. Among authors: boudreault pl. J Med Chem. 2022 Jan 13;65(1):531-551. doi: 10.1021/acs.jmedchem.1c01708. Epub 2022 Jan 4. J Med Chem. 2022. PMID: 34982553
Signaling Modulation via Minimal C-Terminal Modifications of Apelin-13.
Théroux L, Van Den Hauwe R, Trân K, Fournier J, Desgagné M, Meneboo N, Lavallée A, Fröhlich U, Côté J, Hollanders C, Longpré JM, Murza A, Marsault E, Sarret P, Boudreault PL, Ballet S. Théroux L, et al. Among authors: boudreault pl. ACS Pharmacol Transl Sci. 2023 Jan 26;6(2):290-305. doi: 10.1021/acsptsci.2c00219. eCollection 2023 Feb 10. ACS Pharmacol Transl Sci. 2023. PMID: 36798478 Free PMC article.
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