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Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.
Vantieghem T, Aslam NA, Osipov EM, Akele M, Van Belle S, Beelen S, Drexler M, Paulovcakova T, Lux V, Fearon D, Douangamath A, von Delft F, Christ F, Veverka V, Verwilst P, Van Aerschot A, Debyser Z, Strelkov SV. Vantieghem T, et al. Among authors: drexler m. Eur J Med Chem. 2024 Oct 11;280:116960. doi: 10.1016/j.ejmech.2024.116960. Online ahead of print. Eur J Med Chem. 2024. PMID: 39461037
Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.
Kocek H, Chalupská D, Dejmek M, Dvořáková A, Zgarbová M, Šála M, Chalupský K, Krafčíková P, Otava T, Drexler M, Procházková E, Klepetářová B, Štefek M, Kozic J, Mertlíková-Kaiserová H, Boura E, Weber J, Nencka R. Kocek H, et al. Among authors: drexler m. RSC Med Chem. 2024 Aug 1;15(10):3469-76. doi: 10.1039/d4md00422a. Online ahead of print. RSC Med Chem. 2024. PMID: 39220762 Free PMC article.
Aurora: a fluorescent deoxyribozyme for high-throughput screening.
Volek M, Kurfürst J, Drexler M, Svoboda M, Srb P, Veverka V, Curtis EA. Volek M, et al. Among authors: drexler m. Nucleic Acids Res. 2024 Aug 27;52(15):9049-9061. doi: 10.1093/nar/gkae467. Nucleic Acids Res. 2024. PMID: 38860424 Free PMC article.
181 results