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Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity.
Leonard EK, Tomala J, Gould JR, Leff MI, Lin JX, Li P, Porter MJ, Johansen ER, Thompson L, Cao SD, Hou S, Henclova T, Huliciak M, Sargunas PR, Fabilane CS, Vaněk O, Kovar M, Schneider B, Raimondi G, Leonard WJ, Spangler JB. Leonard EK, et al. Among authors: leonard wj. JCI Insight. 2024 Sep 24;9(18):e173469. doi: 10.1172/jci.insight.173469. JCI Insight. 2024. PMID: 39115939 Free PMC article.
Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds.
Yang H, Ulge UY, Quijano-Rubio A, Bernstein ZJ, Maestas DR, Chun JH, Wang W, Lin JX, Jude KM, Singh S, Orcutt-Jahns BT, Li P, Mou J, Chung L, Kuo YH, Ali YH, Meyer AS, Grayson WL, Heller NM, Garcia KC, Leonard WJ, Silva DA, Elisseeff JH, Baker D, Spangler JB. Yang H, et al. Among authors: leonard wj. Nat Chem Biol. 2023 Sep;19(9):1127-1137. doi: 10.1038/s41589-023-01313-6. Epub 2023 Apr 6. Nat Chem Biol. 2023. PMID: 37024727 Free PMC article.
Engineered cytokine/antibody fusion proteins improve delivery of IL-2 to pro-inflammatory cells and promote antitumor activity.
Leonard EK, Tomala J, Gould JR, Leff MI, Lin JX, Li P, Porter MJ, Johansen ER, Thompson L, Cao SD, Henclova T, Huliciak M, Vaněk O, Kovar M, Leonard WJ, Spangler JB. Leonard EK, et al. Among authors: leonard wj. bioRxiv [Preprint]. 2023 May 4:2023.05.03.539272. doi: 10.1101/2023.05.03.539272. bioRxiv. 2023. Update in: JCI Insight. 2024 Sep 24;9(18):e173469. doi: 10.1172/jci.insight.173469 PMID: 37205604 Free PMC article. Updated. Preprint.
Potent antitumor activity of a designed interleukin-21 mimic.
Chun JH, Lim BS, Roy S, Walsh MJ, Abhiraman GC, Zhangxu K, Atajanova T, Revach OY, Clark EC, Li P, Palin CA, Khanna A, Tower S, Kureshi R, Hoffman MT, Sharova T, Lawless A, Cohen S, Boland GM, Nguyen T, Peprah F, Tello JG, Liu SY, Kim CJ, Shin H, Quijano-Rubio A, Jude KM, Gerben S, Murray A, Heine P, DeWitt M, Ulge UY, Carter L, King NP, Silva DA, Kueh HY, Kalia V, Sarkar S, Jenkins RW, Garcia KC, Leonard WJ, Dougan M, Dougan SK, Baker D. Chun JH, et al. Among authors: leonard wj. bioRxiv [Preprint]. 2024 Dec 7:2024.12.06.626481. doi: 10.1101/2024.12.06.626481. bioRxiv. 2024. PMID: 39677740 Free PMC article. Preprint.
Crosstalk between ILC2s and Th2 cells varies among mouse models.
Gurram RK, Wei D, Yu Q, Butcher MJ, Chen X, Cui K, Hu G, Zheng M, Zhu X, Oh J, Sun B, Urban JF Jr, Zhao K, Leonard WJ, Zhu J. Gurram RK, et al. Among authors: leonard wj. Cell Rep. 2023 Feb 28;42(2):112073. doi: 10.1016/j.celrep.2023.112073. Epub 2023 Feb 2. Cell Rep. 2023. PMID: 36735533 Free PMC article.
367 results