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361 results

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Page 1
Mechanism of neurodegeneration mediated by clonal inflammatory microglia.
Vicario R, Fragkogianni S, Pokrovskii M, Mayer C, Lopez-Rodrigo E, Hu Y, Ogishi M, Alberdi A, Baako A, Ay O, Plu I, Sazdovitch V, Heritier S, Cohen-Aubart F, Shor N, Miyara M, Nguyen-Khac F, Viale A, Idbaih A, Amoura Z, Rosenblum MK, Zhang H, Karnoub ER, Sashittal P, Jakatdar A, Iacobuzio-Donahue CA, Abdel-Wahab O, Tabar V, Socci ND, Elemento O, Diamond EL, Boisson B, Casanova JL, Seilhean D, Haroche J, Donadieu J, Geissmann F. Vicario R, et al. Among authors: abdel wahab o. bioRxiv [Preprint]. 2024 Jul 31:2024.07.30.605867. doi: 10.1101/2024.07.30.605867. bioRxiv. 2024. PMID: 39131366 Free PMC article. Preprint.
A microglia clonal inflammatory disorder in Alzheimer's Disease.
Vicario R, Fragkogianni S, Weber L, Lazarov T, Hu Y, Hayashi SY, Craddock BP, Socci ND, Alberdi A, Baako A, Ay O, Ogishi M, Lopez-Rodrigo E, Kappagantula R, Viale A, Iacobuzio-Donahue CA, Zhou T, Ransohoff RM, Chesworth R; Netherlands Brain Bank; Abdel-Wahab O, Boisson B, Elemento O, Casanova JL, Miller WT, Geissmann F. Vicario R, et al. bioRxiv [Preprint]. 2024 Aug 3:2024.01.25.577216. doi: 10.1101/2024.01.25.577216. bioRxiv. 2024. PMID: 38328106 Free PMC article. Preprint.
A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies.
Liu X, Devadiga SA, Stanley RF, Morrow R, Janssen K, Quesnel-Vallières M, Pomp O, Moverley AA, Li C, Skuli N, Carroll MP, Huang J, Wallace DC, Lynch KW, Abdel-Wahab O, Klein PS. Liu X, et al. bioRxiv [Preprint]. 2024 Apr 23:2023.06.25.546449. doi: 10.1101/2023.06.25.546449. bioRxiv. 2024. Update in: J Clin Invest. 2024 May 7;134(12):e175619. doi: 10.1172/JCI175619 PMID: 38712254 Free PMC article. Updated. Preprint.
Covalent Targeting of Splicing in T Cells.
Scott KA, Kojima H, Ropek N, Warren CD, Zhang TL, Hogg SJ, Webster C, Zhang X, Rahman J, Melillo B, Cravatt BF, Lyu J, Abdel-Wahab O, Vinogradova EV. Scott KA, et al. bioRxiv [Preprint]. 2023 Dec 18:2023.12.18.572199. doi: 10.1101/2023.12.18.572199. bioRxiv. 2023. Update in: Cell Chem Biol. 2024 Nov 22:S2451-9456(24)00445-8. doi: 10.1016/j.chembiol.2024.10.010 PMID: 38187674 Free PMC article. Updated. Preprint.
RBM10 loss induces aberrant splicing of cytoskeletal and extracellular matrix mRNAs and promotes metastatic fitness.
Krishnamoorthy GP, Glover AR, Untch BR, Sigcha-Coello N, Xu B, Vukel D, Liu Y, Tiedje V, Berman K, Tamarapu PP, Acuña-Ruiz A, Saqcena M, de Stanchina E, Boucai L, Ghossein RA, Knauf JA, Abdel-Wahab O, Bradley RK, Fagin JA. Krishnamoorthy GP, et al. bioRxiv [Preprint]. 2024 Jul 10:2024.07.09.602730. doi: 10.1101/2024.07.09.602730. bioRxiv. 2024. PMID: 39026820 Free PMC article. Preprint.
Covalent targeting of splicing in T cells.
Scott KA, Kojima H, Ropek N, Warren CD, Zhang TL, Hogg SJ, Sanford H, Webster C, Zhang X, Rahman J, Melillo B, Cravatt BF, Lyu J, Abdel-Wahab O, Vinogradova EV. Scott KA, et al. Among authors: abdel wahab o. Cell Chem Biol. 2024 Nov 22:S2451-9456(24)00445-8. doi: 10.1016/j.chembiol.2024.10.010. Online ahead of print. Cell Chem Biol. 2024. PMID: 39591969
The effect of methylation on the let-7-BCL2L1-BCL2 axis and the potential use of hypomethylating and BH3 mimetic drugs in histiocytic neoplasms.
Salmon-Divon M, Meyuchas R, Shpilberg O, Okon E, Benhamida J, Yabe M, Petrova-Drus K, Zvida-Bloch T, Basood M, Mazor R, Durham BH, Haroche J, Abdel-Wahab O, Diamond EL, Hershkovitz-Rokah O. Salmon-Divon M, et al. Among authors: abdel wahab o. Leukemia. 2024 Nov 8. doi: 10.1038/s41375-024-02459-5. Online ahead of print. Leukemia. 2024. PMID: 39516372 No abstract available.
Phase I First-in-Human Dose Escalation Study of the oral Casein Kinase 1α and Cyclin Dependent Kinase 7/9 inhibitor BTX-A51 in advanced MDS and AML.
Ball B, Xiao W, Borthakur G, Nguyen LXT, Valerio M, Venkatachalam A, Marcucci G, Stein A, Thai DL, Cook D, Chan K, Persaud S, Levine R, Abdel-Wahab O, Ben-Neriah Y, Stein E. Ball B, et al. Among authors: abdel wahab o. Res Sq [Preprint]. 2024 Oct 15:rs.3.rs-4954060. doi: 10.21203/rs.3.rs-4954060/v1. Res Sq. 2024. PMID: 39483885 Free PMC article. Preprint.
Contemporary Approach to the Diagnosis and Classification of Myelodysplastic Neoplasms/Syndromes-Recommendations From the International Consortium for Myelodysplastic Neoplasms/Syndromes (MDS [icMDS]).
Aakash F, Gisriel SD, Zeidan AM, Bennett JM, Bejar R, Bewersdorf JP, Borate UM, Boultwood J, Brunner AM, Buckstein R, Carraway HE, Churpek JE, Daver NG, DeZern AE, Efficace F, Fenaux P, Figueroa ME, Garcia-Manero G, Gore SD, Greenberg PL, Griffiths EA, Halene S, Hourigan CS, Kim TK, Kim N, Komrokji RS, Kutchroo VK, List AF, Little RF, Majeti R, Nazha A, Nimer SD, Odenike O, Padron E, Patnaik MM, Platzbecker U, Della Porta MG, Roboz GJ, Sallman DA, Santini V, Sanz G, Savona MR, Sekeres MA, Stahl M, Starczynowski DT, Steensma DP, Taylor J, Abdel-Wahab O, Wei AH, Xie Z, Xu ML, Hasserjian RP, Loghavi S. Aakash F, et al. Among authors: abdel wahab o. Mod Pathol. 2024 Dec;37(12):100615. doi: 10.1016/j.modpat.2024.100615. Epub 2024 Sep 23. Mod Pathol. 2024. PMID: 39322118 Review.
361 results