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The human microglial surveillant phenotype is preserved by de novo neurosteroidogenesis through the control of cholesterol homeostasis: Crucial role of 18 kDa Translocator Protein.
Angeloni E, Germelli L, Marchetti L, Da Pozzo E, Tremolanti C, Wetzel CH, Baglini E, Taliani S, Da Settimo F, Martini C, Costa B. Angeloni E, et al. Among authors: martini c. Biochim Biophys Acta Mol Basis Dis. 2023 Aug;1869(6):166751. doi: 10.1016/j.bbadis.2023.166751. Epub 2023 May 9. Biochim Biophys Acta Mol Basis Dis. 2023. PMID: 37169037 Free article.
Apolipoprotein E ε4 triggers neurotoxicity via cholesterol accumulation, acetylcholine dyshomeostasis, and PKCε mislocalization in cholinergic neuronal cells.
Piccarducci R, Giacomelli C, Bertilacchi MS, Benito-Martinez A, Di Giorgi N, Daniele S, Signore G, Rocchiccioli S, Vilar M, Marchetti L, Martini C. Piccarducci R, et al. Among authors: martini c. Biochim Biophys Acta Mol Basis Dis. 2023 Oct;1869(7):166793. doi: 10.1016/j.bbadis.2023.166793. Epub 2023 Jun 17. Biochim Biophys Acta Mol Basis Dis. 2023. PMID: 37336366 Free article.
Drug Mechanism: A bioinformatic update.
Cirinciani M, Da Pozzo E, Trincavelli ML, Milazzo P, Martini C. Cirinciani M, et al. Among authors: martini c. Biochem Pharmacol. 2024 Oct;228:116078. doi: 10.1016/j.bcp.2024.116078. Epub 2024 Feb 23. Biochem Pharmacol. 2024. PMID: 38402909 Review.
Human oligodendrocyte-like cell differentiation is promoted by TSPO-mediated endogenous steroidogenesis.
Tremolanti C, Angeloni E, Da Pozzo E, Germelli L, Giacomelli C, Scalzi E, Taliani S, Da Settimo F, Mensah-Nyagan AG, Martini C, Costa B. Tremolanti C, et al. Among authors: martini c. Biochim Biophys Acta Mol Basis Dis. 2024 Jun;1870(5):167174. doi: 10.1016/j.bbadis.2024.167174. Epub 2024 Apr 15. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 38631406 Free article.
Design, synthesis and biological evaluation of new H2S-releasing rivastigmine derivatives as neuroprotective molecules.
Sestito S, Cirone I, Sagona S, Runfola M, Raffellini L, La Rocca V, Citi V, Martelli A, Daniele S, Lai M, Calderone V, Martini C, Manera C, Rapposelli S. Sestito S, et al. Among authors: martini c. Eur J Med Chem. 2025 Feb 5;283:117175. doi: 10.1016/j.ejmech.2024.117175. Epub 2024 Dec 17. Eur J Med Chem. 2025. PMID: 39705734 Free article.
Neurosteroids and Translocator Protein (TSPO) in neuroinflammation.
Angeloni E, Germelli L, Costa B, Martini C, Da Pozzo E. Angeloni E, et al. Among authors: martini c. Neurochem Int. 2025 Jan;182:105916. doi: 10.1016/j.neuint.2024.105916. Epub 2024 Dec 15. Neurochem Int. 2025. PMID: 39681140 Review.
1,056 results