Hypoxic niches are endowed with a protumorigenic mechanism that supersedes the protective function of PTEN.
Nascimento-Filho CHV, Webber LP, Borgato GB, Goloni-Bertollo EM, Squarize CH, Castilho RM.
Nascimento-Filho CHV, et al.
FASEB J. 2019 Dec;33(12):13435-13449. doi: 10.1096/fj.201900722R. Epub 2019 Sep 27.
FASEB J. 2019.
PMID: 31560860
Free PMC article.
Furthermore, our data suggest that targeted therapies aiming at the PTEN/PI3K signaling may constitute an effective strategy to counteract the development of intratumoral hypoxia and the accumulation of CSCs.-Nascimento-Filho, C. H. V., Webber, L. P., Borgato, G. B. …
Furthermore, our data suggest that targeted therapies aiming at the PTEN/PI3K signaling may constitute an effective strategy to counteract t …