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Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM.
Ito F, Li Z, Minakhin L, Chandramouly G, Tyagi M, Betsch R, Krais JJ, Taberi B, Vekariya U, Calbert M, Skorski T, Johnson N, Chen XS, Pomerantz RT. Ito F, et al. Among authors: skorski t. Nat Commun. 2024 Aug 14;15(1):7003. doi: 10.1038/s41467-024-51351-4. Nat Commun. 2024. PMID: 39143110 Free PMC article.
Polθ Inhibition: An Anticancer Therapy for HR-Deficient Tumours.
Barszczewska-Pietraszek G, Drzewiecka M, Czarny P, Skorski T, Śliwiński T. Barszczewska-Pietraszek G, et al. Among authors: skorski t. Int J Mol Sci. 2022 Dec 24;24(1):319. doi: 10.3390/ijms24010319. Int J Mol Sci. 2022. PMID: 36613762 Free PMC article. Review.
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors.
Fried W, Tyagi M, Minakhin L, Chandramouly G, Tredinnick T, Ramanjulu M, Auerbacher W, Calbert M, Rusanov T, Hoang T, Borisonnik N, Betsch R, Krais JJ, Wang Y, Vekariya UM, Gordon J, Morton G, Kent T, Skorski T, Johnson N, Childers W, Chen XS, Pomerantz RT. Fried W, et al. Among authors: skorski t. Nat Commun. 2024 Apr 5;15(1):2862. doi: 10.1038/s41467-024-46593-1. Nat Commun. 2024. PMID: 38580648 Free PMC article.
DNA polymerase theta-mediated DNA repair is a functional dependency and therapeutic vulnerability in DNMT3A deficient leukemia cells.
Le BV, Vekariya U, Toma MM, Nieborowska-Skorska M, Caron MC, Gozdecka M, Haydar Z, Walsh M, Ghosh J, Vaughan-Williams E, Podszywalow-Bartnicka P, Kukuyan AM, Ziolkowska S, Hadzijusufovic E, Chandramouly G, Piwocka K, Pomerantz R, Vassiliou GS, Huntly BJ, Valent P, Bellacosa A, Masson JY, Gupta GP, Challen GA, Skorski T. Le BV, et al. Among authors: skorski t. bioRxiv [Preprint]. 2024 Sep 19:2024.09.15.613155. doi: 10.1101/2024.09.15.613155. bioRxiv. 2024. PMID: 39411165 Free PMC article. Preprint.
TIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment.
Wolczyk M, Serwa R, Kominek A, Klejman A, Milek J, Chwałek M, Turos-Korgul L, Charzyńska A, Dabrowski M, Dziembowska M, Skorski T, Piwocka K, Podszywalow-Bartnicka P. Wolczyk M, et al. Among authors: skorski t. iScience. 2023 Mar 31;26(4):106543. doi: 10.1016/j.isci.2023.106543. eCollection 2023 Apr 21. iScience. 2023. PMID: 37123244 Free PMC article.
211 results