Race PR - Search Results

1

Antibiotic origami: selective formation of spirotetronates in abyssomicin biosynthesis.

Mbatha SZ, Back CR, Devine AJ, Mulliner HM, Johns ST, Lewin H, Cheung KA, Zorn K, Stach JEM, Hayes MA, van der Kamp MW, Race PR, Willis CL. Mbatha SZ, et al. Among authors: race pr. Chem Sci. 2024 Aug 12;15(34):14009-15. doi: 10.1039/d4sc03253e. Online ahead of print. Chem Sci. 2024. PMID: 39144453 Free PMC article.

2

Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954.

Race PR, Lovering AL, White SA, Grove JI, Searle PF, Wrighton CW, Hyde EI. Race PR, et al. J Mol Biol. 2007 Apr 27;368(2):481-92. doi: 10.1016/j.jmb.2007.02.012. Epub 2007 Feb 11. J Mol Biol. 2007. PMID: 17350040

3

Conformation of the EPEC Tir protein in solution: investigating the impact of serine phosphorylation at positions 434/463.

Race PR, Solovyova AS, Banfield MJ. Race PR, et al. Biophys J. 2007 Jul 15;93(2):586-96. doi: 10.1529/biophysj.106.101766. Epub 2007 Apr 20. Biophys J. 2007. PMID: 17449672 Free PMC article.

4

Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954.

Grove JI, Lovering AL, Guise C, Race PR, Wrighton CJ, White SA, Hyde EI, Searle PF. Grove JI, et al. Among authors: race pr. Cancer Res. 2003 Sep 1;63(17):5532-7. Cancer Res. 2003. PMID: 14500391

5

The Catalytic Mechanism of a Natural Diels-Alderase Revealed in Molecular Detail.

Byrne MJ, Lees NR, Han LC, van der Kamp MW, Mulholland AJ, Stach JE, Willis CL, Race PR. Byrne MJ, et al. Among authors: race pr. J Am Chem Soc. 2016 May 18;138(19):6095-8. doi: 10.1021/jacs.6b00232. Epub 2016 May 6. J Am Chem Soc. 2016. PMID: 27140661

6

The Streptococcus gordonii Adhesin CshA Protein Binds Host Fibronectin via a Catch-Clamp Mechanism.

Back CR, Sztukowska MN, Till M, Lamont RJ, Jenkinson HF, Nobbs AH, Race PR. Back CR, et al. Among authors: race pr. J Biol Chem. 2017 Feb 3;292(5):1538-1549. doi: 10.1074/jbc.M116.760975. Epub 2016 Dec 5. J Biol Chem. 2017. PMID: 27920201 Free PMC article.

7

Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics.

Gao SS, Wang L, Song Z, Hothersall J, Stevens ER, Connolly J, Winn PJ, Cox RJ, Crump MP, Race PR, Thomas CM, Simpson TJ, Willis CL. Gao SS, et al. Among authors: race pr. Angew Chem Int Ed Engl. 2017 Mar 27;56(14):3930-3934. doi: 10.1002/anie.201611590. Epub 2017 Feb 9. Angew Chem Int Ed Engl. 2017. PMID: 28181382

8

Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics.

Thistlethwaite IRG, Bull FM, Cui C, Walker PD, Gao SS, Wang L, Song Z, Masschelein J, Lavigne R, Crump MP, Race PR, Simpson TJ, Willis CL. Thistlethwaite IRG, et al. Among authors: race pr. Chem Sci. 2017 Sep 1;8(9):6196-6201. doi: 10.1039/c7sc01670k. Epub 2017 Jul 11. Chem Sci. 2017. PMID: 28989652 Free PMC article.

9

Fine Tuning of Antibiotic Activity by a Tailoring Hydroxylase in a Trans-AT Polyketide Synthase Pathway.

Mohammad HH, Connolly JA, Song Z, Hothersall J, Race PR, Willis CL, Simpson TJ, Winn PJ, Thomas CM. Mohammad HH, et al. Among authors: race pr. Chembiochem. 2018 Apr 16;19(8):836-841. doi: 10.1002/cbic.201800036. Epub 2018 Mar 13. Chembiochem. 2018. PMID: 29363252

10

An Esterase-like Lyase Catalyzes Acetate Elimination in Spirotetronate/Spirotetramate Biosynthesis.

Lees NR, Han LC, Byrne MJ, Davies JA, Parnell AE, Moreland PEJ, Stach JEM, van der Kamp MW, Willis CL, Race PR. Lees NR, et al. Among authors: race pr. Angew Chem Int Ed Engl. 2019 Feb 18;58(8):2305-2309. doi: 10.1002/anie.201812105. Epub 2019 Jan 21. Angew Chem Int Ed Engl. 2019. PMID: 30664319

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