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Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic β cell Pyroptosis upon Viral Infection.
Yang L, Han Y, Zhang T, Dong X, Ge J, Roy A, Zhu J, Lu T, Vandana JJ, de Silva N, Robertson CC, Xiang JZ, Pan C, Sun Y, Que J, Evans T, Liu C, Wang W, Naji A, Parker SCJ, Schwartz RE, Chen S. Yang L, et al. Among authors: liu c. bioRxiv [Preprint]. 2024 Aug 6:2024.08.05.606734. doi: 10.1101/2024.08.05.606734. bioRxiv. 2024. Update in: Cell Stem Cell. 2024 Nov 7;31(11):1612-1629.e8. doi: 10.1016/j.stem.2024.08.007 PMID: 39149298 Free PMC article. Updated. Preprint.
ROCKII inhibition promotes the maturation of human pancreatic beta-like cells.
Ghazizadeh Z, Kao DI, Amin S, Cook B, Rao S, Zhou T, Zhang T, Xiang Z, Kenyon R, Kaymakcalan O, Liu C, Evans T, Chen S. Ghazizadeh Z, et al. Among authors: liu c. Nat Commun. 2017 Aug 21;8(1):298. doi: 10.1038/s41467-017-00129-y. Nat Commun. 2017. PMID: 28824164 Free PMC article.
Discovery of a drug candidate for GLIS3-associated diabetes.
Amin S, Cook B, Zhou T, Ghazizadeh Z, Lis R, Zhang T, Khalaj M, Crespo M, Perera M, Xiang JZ, Zhu Z, Tomishima M, Liu C, Naji A, Evans T, Huangfu D, Chen S. Amin S, et al. Among authors: liu c. Nat Commun. 2018 Jul 11;9(1):2681. doi: 10.1038/s41467-018-04918-x. Nat Commun. 2018. PMID: 29992946 Free PMC article.
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.
Yang L, Han Y, Nilsson-Payant BE, Gupta V, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffré F, Zhang T, Kim TW, Harschnitz O, Redmond D, Houghton S, Liu C, Naji A, Ciceri G, Guttikonda S, Bram Y, Nguyen DT, Cioffi M, Chandar V, Hoagland DA, Huang Y, Xiang J, Wang H, Lyden D, Borczuk A, Chen HJ, Studer L, Pan FC, Ho DD, tenOever BR, Evans T, Schwartz RE, Chen S. Yang L, et al. Among authors: liu c. Cell Stem Cell. 2020 Jul 2;27(1):125-136.e7. doi: 10.1016/j.stem.2020.06.015. Epub 2020 Jun 19. Cell Stem Cell. 2020. PMID: 32579880 Free PMC article.
SARS-CoV-2 infection induces beta cell transdifferentiation.
Tang X, Uhl S, Zhang T, Xue D, Li B, Vandana JJ, Acklin JA, Bonnycastle LL, Narisu N, Erdos MR, Bram Y, Chandar V, Chong ACN, Lacko LA, Min Z, Lim JK, Borczuk AC, Xiang J, Naji A, Collins FS, Evans T, Liu C, tenOever BR, Schwartz RE, Chen S. Tang X, et al. Among authors: liu c. Cell Metab. 2021 Aug 3;33(8):1577-1591.e7. doi: 10.1016/j.cmet.2021.05.015. Epub 2021 May 19. Cell Metab. 2021. PMID: 34081913 Free PMC article.
An integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D associated genes and regulatory signals.
Zhao Z, D'Oliveira Albanus R, Taylor H, Tang X, Han Y, Orchard P, Varshney A, Zhang T, Manickam N, Erdos M, Narisu N, Taylor L, Saavedra X, Zhong A, Li B, Zhou T, Naji A, Liu C, Collins F, Parker SC, Chen S. Zhao Z, et al. Among authors: liu c. Res Sq [Preprint]. 2023 Oct 18:rs.3.rs-3343318. doi: 10.21203/rs.3.rs-3343318/v1. Res Sq. 2023. PMID: 37886586 Free PMC article. Preprint.
Checkpoint kinase 2 controls insulin secretion and glucose homeostasis.
Chong ACN, Vandana JJ, Jeng G, Li G, Meng Z, Duan X, Zhang T, Qiu Y, Duran-Struuck R, Coker K, Wang W, Li Y, Min Z, Zuo X, de Silva N, Chen Z, Naji A, Hao M, Liu C, Chen S. Chong ACN, et al. Among authors: liu c. Nat Chem Biol. 2024 May;20(5):566-576. doi: 10.1038/s41589-023-01466-4. Epub 2023 Nov 9. Nat Chem Biol. 2024. PMID: 37945898 Free PMC article.
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