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Single-molecule studies reveal the off-pathway early paused state intermediates as a target of streptolydigin inhibition of RNA polymerase and its dramatic enhancement by Gre factors.
Arseniev A, Panfilov M, Pobegalov G, Potyseva A, Pavlinova P, Yakunina M, Lee J, Borukhov S, Severinov K, Khodorkovskii M. Arseniev A, et al. Among authors: pobegalov g. Nucleic Acids Res. 2024 Dec 5:gkae1135. doi: 10.1093/nar/gkae1135. Online ahead of print. Nucleic Acids Res. 2024. PMID: 39656915
An extrinsic motor directs chromatin loop formation by cohesin.
Guérin TM, Barrington C, Pobegalov G, Molodtsov MI, Uhlmann F. Guérin TM, et al. Among authors: pobegalov g. EMBO J. 2024 Oct;43(19):4173-4196. doi: 10.1038/s44318-024-00202-5. Epub 2024 Aug 19. EMBO J. 2024. PMID: 39160275 Free PMC article.
Mechanical disengagement of the cohesin ring.
Richeldi M, Pobegalov G, Higashi TL, Gmurczyk K, Uhlmann F, Molodtsov MI. Richeldi M, et al. Among authors: pobegalov g. Nat Struct Mol Biol. 2024 Jan;31(1):23-31. doi: 10.1038/s41594-023-01122-4. Epub 2023 Oct 23. Nat Struct Mol Biol. 2024. PMID: 37872232 Free PMC article.
Establishment of dsDNA-dsDNA interactions by the condensin complex.
Tang M, Pobegalov G, Tanizawa H, Chen ZA, Rappsilber J, Molodtsov M, Noma KI, Uhlmann F. Tang M, et al. Among authors: pobegalov g. Mol Cell. 2023 Nov 2;83(21):3787-3800.e9. doi: 10.1016/j.molcel.2023.09.019. Epub 2023 Oct 10. Mol Cell. 2023. PMID: 37820734 Free PMC article.
Single-molecule studies reveal the off-pathway elemental pause state as a target of streptolydigin inhibition of RNA polymerase and its dramatic enhancement by Gre factors.
Arseniev A, Panfilov M, Pobegalov G, Potyseva A, Pavlinova P, Yakunina M, Lee J, Borukhov S, Severinov K, Khodorkovskii M. Arseniev A, et al. Among authors: pobegalov g. bioRxiv [Preprint]. 2023 Jun 5:2023.06.05.542125. doi: 10.1101/2023.06.05.542125. bioRxiv. 2023. Update in: Nucleic Acids Res. 2024 Dec 05:gkae1135. doi: 10.1093/nar/gkae1135 PMID: 37333075 Free PMC article. Updated. Preprint.
Single-molecule characterization of compressed RecA nucleoprotein filaments.
Alekseev A, Morozova N, Vedyaykin A, Yakimov A, Khodorkovskii M, Pobegalov G. Alekseev A, et al. Among authors: pobegalov g. Biochem Biophys Res Commun. 2022 Jul 23;614:29-33. doi: 10.1016/j.bbrc.2022.04.130. Epub 2022 Apr 30. Biochem Biophys Res Commun. 2022. PMID: 35567941
21 results