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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM. Sancak Y, et al. Among authors: sabatini dm. Mol Cell. 2007 Mar 23;25(6):903-15. doi: 10.1016/j.molcel.2007.03.003. Mol Cell. 2007. PMID: 17386266 Free article.
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM. Sancak Y, et al. Among authors: sabatini dm. Science. 2008 Jun 13;320(5882):1496-501. doi: 10.1126/science.1157535. Epub 2008 May 22. Science. 2008. PMID: 18497260 Free PMC article.
Rag proteins regulate amino-acid-induced mTORC1 signalling.
Sancak Y, Sabatini DM. Sancak Y, et al. Among authors: sabatini dm. Biochem Soc Trans. 2009 Feb;37(Pt 1):289-90. doi: 10.1042/BST0370289. Biochem Soc Trans. 2009. PMID: 19143648 Free PMC article. Review.
Rapamycin inhibits mTORC1, but not completely.
Thoreen CC, Sabatini DM. Thoreen CC, et al. Among authors: sabatini dm. Autophagy. 2009 Jul;5(5):725-6. doi: 10.4161/auto.5.5.8504. Epub 2009 Jul 22. Autophagy. 2009. PMID: 19395872
mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis.
Laplante M, Sabatini DM. Laplante M, et al. Among authors: sabatini dm. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3281-2. doi: 10.1073/pnas.1000323107. Epub 2010 Feb 18. Proc Natl Acad Sci U S A. 2010. PMID: 20167806 Free PMC article. No abstract available.
266 results