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Spatial transcriptomic validation of a biomimetic model of fibrosis enables re-evaluation of a therapeutic antibody targeting LOXL2.
Bell JA, Davies ER, Brereton CJ, Vukmirovic M, Roberts JJW, Lunn K, Wickens L, Conforti F, Ridley RA, Ceccato J, Sayer LN, Johnston DA, Vallejo AF, Alzetani A, Jogai S, Marshall BG, Fabre A, Richeldi L, Monk PD, Skipp P, Kaminski N, Offer E, Wang Y, Davies DE, Jones MG. Bell JA, et al. Among authors: johnston da. Cell Rep Med. 2024 Sep 17;5(9):101695. doi: 10.1016/j.xcrm.2024.101695. Epub 2024 Aug 21. Cell Rep Med. 2024. PMID: 39173635 Free PMC article.
A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection.
Blume C, Jackson CL, Spalluto CM, Legebeke J, Nazlamova L, Conforti F, Perotin JM, Frank M, Butler J, Crispin M, Coles J, Thompson J, Ridley RA, Dean LSN, Loxham M, Reikine S, Azim A, Tariq K, Johnston DA, Skipp PJ, Djukanovic R, Baralle D, McCormick CJ, Davies DE, Lucas JS, Wheway G, Mennella V. Blume C, et al. Among authors: johnston da. Nat Genet. 2021 Feb;53(2):205-214. doi: 10.1038/s41588-020-00759-x. Epub 2021 Jan 11. Nat Genet. 2021. PMID: 33432184
Spatially resolved deconvolution of the fibrotic niche in lung fibrosis.
Eyres M, Bell JA, Davies ER, Fabre A, Alzetani A, Jogai S, Marshall BG, Johnston DA, Xu Z, Fletcher SV, Wang Y, Marshall G, Davies DE, Offer E, Jones MG. Eyres M, et al. Among authors: johnston da. Cell Rep. 2022 Aug 16;40(7):111230. doi: 10.1016/j.celrep.2022.111230. Cell Rep. 2022. PMID: 35977489 Free PMC article.
Patient-derived tumor organoid and fibroblast assembloid models for interrogation of the tumor microenvironment in esophageal adenocarcinoma.
Sharpe BP, Nazlamova LA, Tse C, Johnston DA, Thomas J, Blyth R, Pickering OJ, Grace B, Harrington J, Rajak R, Rose-Zerilli M, Walters ZS, Underwood TJ. Sharpe BP, et al. Among authors: johnston da. Cell Rep Methods. 2024 Dec 16;4(12):100909. doi: 10.1016/j.crmeth.2024.100909. Epub 2024 Nov 27. Cell Rep Methods. 2024. PMID: 39610249 Free PMC article.
Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α.
Tezera LB, Bielecka MK, Ogongo P, Walker NF, Ellis M, Garay-Baquero DJ, Thomas K, Reichmann MT, Johnston DA, Wilkinson KA, Ahmed M, Jogai S, Jayasinghe SN, Wilkinson RJ, Mansour S, Thomas GJ, Ottensmeier CH, Leslie A, Elkington PT. Tezera LB, et al. Among authors: johnston da. Elife. 2020 Feb 24;9:e52668. doi: 10.7554/eLife.52668. Elife. 2020. PMID: 32091388 Free PMC article.
Ex-vivo models of the Retinal Pigment Epithelium (RPE) in long-term culture faithfully recapitulate key structural and physiological features of native RPE.
Lynn SA, Ward G, Keeling E, Scott JA, Cree AJ, Johnston DA, Page A, Cuan-Urquizo E, Bhaskar A, Grossel MC, Tumbarello DA, Newman TA, Lotery AJ, Ratnayaka JA. Lynn SA, et al. Among authors: johnston da. Tissue Cell. 2017 Aug;49(4):447-460. doi: 10.1016/j.tice.2017.06.003. Epub 2017 Jun 19. Tissue Cell. 2017. PMID: 28669519 Free PMC article.
Microglial morphology in Alzheimer's disease and after Aβ immunotherapy.
Franco-Bocanegra DK, Gourari Y, McAuley C, Chatelet DS, Johnston DA, Nicoll JAR, Boche D. Franco-Bocanegra DK, et al. Among authors: johnston da. Sci Rep. 2021 Aug 5;11(1):15955. doi: 10.1038/s41598-021-95535-0. Sci Rep. 2021. PMID: 34354209 Free PMC article.
352 results