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Nicorandil antiallodynic activity in a model of neuropathic pain is associated with the activation of ATP-dependent potassium channels and opioidergic pathways, and reduced production of cytokines and neutrophils recruitment in paw, sciatic nerve, and dorsal root ganglia.
Braga AV, Morais MÍ, Delfino DGS, Costa SOAM, Barbosa BCM, Rodrigues FF, Melo ISF, Matos RC, Castro BFM, Cunha Júnior AS, Braga TC, de Fátima Â, Coelho MM, Machado RR. Braga AV, et al. Among authors: coelho mm. Pharmacol Rep. 2024 Oct;76(5):1067-1078. doi: 10.1007/s43440-024-00640-2. Epub 2024 Aug 23. Pharmacol Rep. 2024. PMID: 39179890
2-Phthalimidethanol and 2-phthalimidethyl nitrate inhibit mechanical allodynia, neutrophil recruitment and cytokine and chemokine production in a murine model of articular inflammation.
Godin AM, Araújo DP, Menezes RR, de Brito AMS, Melo ISF, Coura GME, Bastos LFS, Amaral FA, Teixeira MM, de Fátima Â, Coelho MM, Machado RR. Godin AM, et al. Among authors: coelho mm. Pharmacol Rep. 2017 Aug;69(4):691-695. doi: 10.1016/j.pharep.2017.01.033. Epub 2017 Feb 8. Pharmacol Rep. 2017. PMID: 28550800
Thiamine and riboflavin inhibit production of cytokines and increase the anti-inflammatory activity of a corticosteroid in a chronic model of inflammation induced by complete Freund's adjuvant.
Menezes RR, Godin AM, Rodrigues FF, Coura GME, Melo ISF, Brito AMS, Bertollo CM, Paulino TP, Rachid MA, Machado RR, Coelho MM. Menezes RR, et al. Among authors: coelho mm. Pharmacol Rep. 2017 Oct;69(5):1036-1043. doi: 10.1016/j.pharep.2017.04.011. Epub 2017 Apr 23. Pharmacol Rep. 2017. PMID: 28958614
Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms.
Augusto PSA, Braga AV, Rodrigues FF, Morais MI, Dutra MMGB, Batista CRA, Melo ISF, Costa SOAM, Goulart FA, Coelho MM, Machado RR. Augusto PSA, et al. Among authors: coelho mm. Eur J Pharmacol. 2019 Sep 5;858:172497. doi: 10.1016/j.ejphar.2019.172497. Epub 2019 Jun 22. Eur J Pharmacol. 2019. PMID: 31238066 Free article.
The phthalimide analogues N-3-hydroxypropylphthalimide and N-carboxymethyl-3-nitrophthalimide exhibit activity in experimental models of inflammatory and neuropathic pain.
Batista CRA, Godin AM, Melo ISF, Coura GME, Matsui TC, Dutra MMGB, Brito AMS, Canhestro WG, Alves RJ, Araújo DP, de Fátima Â, Machado RR, Coelho MM. Batista CRA, et al. Among authors: coelho mm. Pharmacol Rep. 2019 Dec;71(6):1177-1183. doi: 10.1016/j.pharep.2019.08.001. Epub 2019 Aug 17. Pharmacol Rep. 2019. PMID: 31669881
Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-α production.
Augusto PSA, Matsui TC, Braga AV, Rodrigues FF, Morais MI, Dutra MMGB, Batista CRA, Melo ISF, Costa SOAM, Bertollo CM, Coelho MM, Machado RR. Augusto PSA, et al. Among authors: coelho mm. Inflammopharmacology. 2022 Feb;30(1):233-241. doi: 10.1007/s10787-021-00899-4. Epub 2021 Nov 30. Inflammopharmacology. 2022. PMID: 34850313
Metformin inhibits paclitaxel-induced mechanical allodynia by activating opioidergic pathways and reducing cytokines production in the dorsal root ganglia and thalamus.
Morais MÍ, Braga AV, Silva RRL, Barbosa BCM, Costa SOAM, Rodrigues FF, Melo ISF, Matos RC, Carobin NV, Sabino AP, Coelho MM, Machado RR. Morais MÍ, et al. Among authors: coelho mm. Cytokine. 2024 Feb;174:156468. doi: 10.1016/j.cyto.2023.156468. Epub 2023 Dec 14. Cytokine. 2024. PMID: 38101167 Free article.
150 results