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Nicorandil antiallodynic activity in a model of neuropathic pain is associated with the activation of ATP-dependent potassium channels and opioidergic pathways, and reduced production of cytokines and neutrophils recruitment in paw, sciatic nerve, and dorsal root ganglia.
Braga AV, Morais MÍ, Delfino DGS, Costa SOAM, Barbosa BCM, Rodrigues FF, Melo ISF, Matos RC, Castro BFM, Cunha Júnior AS, Braga TC, de Fátima Â, Coelho MM, Machado RR. Braga AV, et al. Among authors: morais mi. Pharmacol Rep. 2024 Oct;76(5):1067-1078. doi: 10.1007/s43440-024-00640-2. Epub 2024 Aug 23. Pharmacol Rep. 2024. PMID: 39179890
Metformin antinociceptive effect in models of nociceptive and neuropathic pain is partially mediated by activation of opioidergic mechanisms.
Augusto PSA, Braga AV, Rodrigues FF, Morais MI, Dutra MMGB, Batista CRA, Melo ISF, Costa SOAM, Goulart FA, Coelho MM, Machado RR. Augusto PSA, et al. Among authors: morais mi. Eur J Pharmacol. 2019 Sep 5;858:172497. doi: 10.1016/j.ejphar.2019.172497. Epub 2019 Jun 22. Eur J Pharmacol. 2019. PMID: 31238066 Free article.
Metformin effect in models of inflammation is associated with activation of ATP-dependent potassium channels and inhibition of tumor necrosis factor-α production.
Augusto PSA, Matsui TC, Braga AV, Rodrigues FF, Morais MI, Dutra MMGB, Batista CRA, Melo ISF, Costa SOAM, Bertollo CM, Coelho MM, Machado RR. Augusto PSA, et al. Among authors: morais mi. Inflammopharmacology. 2022 Feb;30(1):233-241. doi: 10.1007/s10787-021-00899-4. Epub 2021 Nov 30. Inflammopharmacology. 2022. PMID: 34850313
4-Methylbenzenecarbothioamide, a hydrogen sulfide donor, inhibits tumor necrosis factor-α and CXCL1 production and exhibits activity in models of pain and inflammation.
Melo ISF, Rodrigues FF, Costa SOAM, Braga AV, Morais MÍ, Vaz JA, Neto LS, Galvão I, Modolo LV, Amaral FA, Oliveira RB, de Fátima Â, Coelho MM, Machado RR. Melo ISF, et al. Among authors: morais mi. Eur J Pharmacol. 2019 Aug 5;856:172404. doi: 10.1016/j.ejphar.2019.172404. Epub 2019 May 24. Eur J Pharmacol. 2019. PMID: 31132352 Free article.
RI75, a curcumin analogue, inhibits tumor necrosis factor-α and interleukin-6 production and exhibits antiallodynic and antiedematogenic activities in mice.
Costa SOAM, Rodrigues IB, Braga AV, Barbosa BCM, Silva RRL, Rodrigues FF, Melo ISF, Morais MÍ, Castro BFM, Júnior ASC, Maltarollo VG, Oliveira RB, Coelho MM, Machado RR. Costa SOAM, et al. Among authors: morais mi. Inflammopharmacology. 2022 Apr;30(2):505-515. doi: 10.1007/s10787-021-00913-9. Epub 2022 Jan 30. Inflammopharmacology. 2022. PMID: 35094257
A clindamycin acetylated derivative with reduced antibacterial activity inhibits articular hyperalgesia and edema by attenuating neutrophil recruitment, NF-κB activation and tumor necrosis factor-α production.
Rodrigues FF, Lino CI, Oliveira VLS, Zaidan I, Melo ISF, Braga AV, Costa SOAM, Morais MI, Barbosa BCM, da Costa YFG, Moreira NF, Alves MS, Braga AD, Carneiro FS, Carvalho AFS, Queiroz-Junior CM, Sousa LP, Amaral FA, Oliveira RB, Coelho MM, Machado RR. Rodrigues FF, et al. Among authors: morais mi. Int Immunopharmacol. 2023 Sep;122:110609. doi: 10.1016/j.intimp.2023.110609. Epub 2023 Jul 8. Int Immunopharmacol. 2023. PMID: 37429145 Free article.
14 results