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Estrogen receptor alpha deficiency in cardiomyocytes reprograms the heart-derived extracellular vesicle proteome and induces obesity in female mice.
Tham YK, Bernardo BC, Claridge B, Yildiz GS, Woon LM, Bond S, Fang H, Ooi JYY, Matsumoto A, Luo J, Tai CMK, Harmawan CA, Kiriazis H, Donner DG, Mellett NA, Abel ED, Khan SA, De Souza DP, Doomun SNE, Liu K, Xiang R, Singh M, Inouye M, Meikle PJ, Weeks KL, Drew BG, Greening DW, McMullen JR. Tham YK, et al. Nat Cardiovasc Res. 2023 Mar;2(3):268-289. doi: 10.1038/s44161-023-00223-z. Epub 2023 Mar 9. Nat Cardiovasc Res. 2023. PMID: 39196021
Phosphoinositide 3-kinase p110α is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction.
Weeks KL, Gao X, Du XJ, Boey EJ, Matsumoto A, Bernardo BC, Kiriazis H, Cemerlang N, Tan JW, Tham YK, Franke TF, Qian H, Bogoyevitch MA, Woodcock EA, Febbraio MA, Gregorevic P, McMullen JR. Weeks KL, et al. Among authors: tham yk. Circ Heart Fail. 2012 Jul 1;5(4):523-34. doi: 10.1161/CIRCHEARTFAILURE.112.966622. Epub 2012 Jun 15. Circ Heart Fail. 2012. PMID: 22705768
Enhanced phosphoinositide 3-kinase(p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes.
Ritchie RH, Love JE, Huynh K, Bernardo BC, Henstridge DC, Kiriazis H, Tham YK, Sapra G, Qin C, Cemerlang N, Boey EJ, Jandeleit-Dahm K, Du XJ, McMullen JR. Ritchie RH, et al. Among authors: tham yk. Diabetologia. 2012 Dec;55(12):3369-81. doi: 10.1007/s00125-012-2720-0. Epub 2012 Sep 22. Diabetologia. 2012. PMID: 23001375
The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice.
Sapra G, Tham YK, Cemerlang N, Matsumoto A, Kiriazis H, Bernardo BC, Henstridge DC, Ooi JY, Pretorius L, Boey EJ, Lim L, Sadoshima J, Meikle PJ, Mellet NA, Woodcock EA, Marasco S, Ueyama T, Du XJ, Febbraio MA, McMullen JR. Sapra G, et al. Among authors: tham yk. Nat Commun. 2014 Dec 9;5:5705. doi: 10.1038/ncomms6705. Nat Commun. 2014. PMID: 25489988 Free article.
17 results