Ganesan A - Search Results

1

Design, Synthesis, and Biological Evaluation of Potent EZH2/LSD1 Dual Inhibitors for Prostate Cancer.

Le M, Lu W, Tan X, Luo B, Yu T, Sun Y, Guo Z, Huang P, Zhu D, Wu Q, Ganesan A, Wen S. Le M, et al. Among authors: ganesan a. J Med Chem. 2024 Sep 12;67(17):15586-15605. doi: 10.1021/acs.jmedchem.4c01250. Epub 2024 Aug 28. J Med Chem. 2024. PMID: 39196854

2

New tranylcypromine derivatives containing sulfonamide motif as potent LSD1 inhibitors to target acute myeloid leukemia: Design, synthesis and biological evaluation.

Liang L, Wang H, Du Y, Luo B, Meng N, Cen M, Huang P, Ganesan A, Wen S. Liang L, et al. Among authors: ganesan a. Bioorg Chem. 2020 Jun;99:103808. doi: 10.1016/j.bioorg.2020.103808. Epub 2020 Apr 17. Bioorg Chem. 2020. PMID: 32334189

3

Synthesis of N-acyl-N,O-acetals mediated by titanium ethoxide.

Li M, Luo B, Liu Q, Hu Y, Ganesan A, Huang P, Wen S. Li M, et al. Among authors: ganesan a. Org Lett. 2014 Jan 3;16(1):10-3. doi: 10.1021/ol4031155. Epub 2013 Dec 5. Org Lett. 2014. PMID: 24308842

4

Macrolactamization versus macrolactonization: total synthesis of FK228, the depsipeptide histone deacetylase inhibitor.

Wen S, Packham G, Ganesan A. Wen S, et al. Among authors: ganesan a. J Org Chem. 2008 Dec 5;73(23):9353-61. doi: 10.1021/jo801866z. J Org Chem. 2008. PMID: 18991384

5

Three-component Pd/Cu-catalyzed cascade reactions of cyclic iodoniums, alkynes, and boronic acids: an approach to methylidenefluorenes.

Zhu D, Wu Y, Wu B, Luo B, Ganesan A, Wu FH, Pi R, Huang P, Wen S. Zhu D, et al. Among authors: ganesan a. Org Lett. 2014 May 2;16(9):2350-3. doi: 10.1021/ol5006714. Epub 2014 Apr 17. Org Lett. 2014. PMID: 24742135

6

Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue.

Wen S, Carey KL, Nakao Y, Fusetani N, Packham G, Ganesan A. Wen S, et al. Among authors: ganesan a. Org Lett. 2007 Mar 15;9(6):1105-8. doi: 10.1021/ol070046y. Epub 2007 Feb 21. Org Lett. 2007. PMID: 17311393

7

The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor.

Yurek-George A, Cecil AR, Mo AH, Wen S, Rogers H, Habens F, Maeda S, Yoshida M, Packham G, Ganesan A. Yurek-George A, et al. Among authors: ganesan a. J Med Chem. 2007 Nov 15;50(23):5720-6. doi: 10.1021/jm0703800. Epub 2007 Oct 24. J Med Chem. 2007. PMID: 17958342

8

Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors.

Benelkebir H, Hodgkinson C, Duriez PJ, Hayden AL, Bulleid RA, Crabb SJ, Packham G, Ganesan A. Benelkebir H, et al. Among authors: ganesan a. Bioorg Med Chem. 2011 Jun 15;19(12):3709-16. doi: 10.1016/j.bmc.2011.02.017. Epub 2011 Feb 13. Bioorg Med Chem. 2011. PMID: 21382717

9

Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A).

Borrello MT, Schinor B, Bartels K, Benelkebir H, Pereira S, Al-Jamal WT, Douglas L, Duriez PJ, Packham G, Haufe G, Ganesan A. Borrello MT, et al. Among authors: ganesan a. Bioorg Med Chem Lett. 2017 May 15;27(10):2099-2101. doi: 10.1016/j.bmcl.2017.03.081. Epub 2017 Mar 29. Bioorg Med Chem Lett. 2017. PMID: 28390942 Free article.

10

Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.

Ho TCS, Chan AHY, Ganesan A. Ho TCS, et al. Among authors: ganesan a. J Med Chem. 2020 Nov 12;63(21):12460-12484. doi: 10.1021/acs.jmedchem.0c00830. Epub 2020 Jul 16. J Med Chem. 2020. PMID: 32608981 Review.

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