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Page 1
Discovery of GuaB inhibitors with efficacy against Acinetobacter baumannii infection.
Kofoed EM, Aliagas I, Crawford T, Mao J, Harris SF, Xu M, Wang S, Wu P, Ma F, Clark K, Sims J, Xu Y, Peng Y, Skippington E, Yang Y, Reeder J, Ubhayakar S, Baumgardner M, Yan Z, Chen J, Park S, Zhang H, Yen C-W, Lorenzo M, Skelton N, Liang X, Chen L, Hoag B, Li CS, Liu Z, Wai J, Liu X, Liang J, Tan MW. Kofoed EM, et al. Among authors: xu m, xu y. mBio. 2024 Oct 16;15(10):e0089724. doi: 10.1128/mbio.00897-24. Epub 2024 Aug 29. mBio. 2024. PMID: 39207111 Free PMC article.
Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Signal Peptidase.
Pantua H, Skippington E, Braun MG, Noland CL, Diao J, Peng Y, Gloor SL, Yan D, Kang J, Katakam AK, Reeder J, Castanedo GM, Garland K, Komuves L, Sagolla M, Austin CD, Murray J, Xu Y, Modrusan Z, Xu M, Hanan EJ, Kapadia SB. Pantua H, et al. Among authors: xu m, xu y. mBio. 2020 Sep 8;11(5):e02018-20. doi: 10.1128/mBio.02018-20. mBio. 2020. PMID: 32900806 Free PMC article.
A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase.
Morisaki JH, Smith PA, Date SV, Kajihara KK, Truong CL, Modrusan Z, Yan D, Kang J, Xu M, Shah IM, Mintzer R, Kofoed EM, Cheung TK, Arnott D, Koehler MF, Heise CE, Brown EJ, Tan MW, Hazenbos WL. Morisaki JH, et al. Among authors: xu m. mBio. 2016 Sep 6;7(5):e00412-16. doi: 10.1128/mBio.00412-16. mBio. 2016. PMID: 27601569 Free PMC article.
Deletion of a previously uncharacterized lipoprotein lirL confers resistance to an inhibitor of type II signal peptidase in Acinetobacter baumannii.
Huang KJ, Pantua H, Diao J, Skippington E, Volny M, Sandoval W, Tiku V, Peng Y, Sagolla M, Yan D, Kang J, Katakam AK, Michaelian N, Reichelt M, Tan MW, Austin CD, Xu M, Hanan E, Kapadia SB. Huang KJ, et al. Among authors: xu m. Proc Natl Acad Sci U S A. 2022 Sep 20;119(38):e2123117119. doi: 10.1073/pnas.2123117119. Epub 2022 Sep 13. Proc Natl Acad Sci U S A. 2022. PMID: 36099298 Free PMC article.
Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA.
Alexander MK, Miu A, Oh A, Reichelt M, Ho H, Chalouni C, Labadie S, Wang L, Liang J, Nickerson NN, Hu H, Yu L, Du M, Yan D, Park S, Kim J, Xu M, Sellers BD, Purkey HE, Skelton NJ, Koehler MFT, Payandeh J, Verma V, Xu Y, Koth CM, Nishiyama M. Alexander MK, et al. Among authors: xu m, xu y. Antimicrob Agents Chemother. 2018 Oct 24;62(11):e01142-18. doi: 10.1128/AAC.01142-18. Print 2018 Nov. Antimicrob Agents Chemother. 2018. PMID: 30104274 Free PMC article.
Optimized arylomycins are a new class of Gram-negative antibiotics.
Smith PA, Koehler MFT, Girgis HS, Yan D, Chen Y, Chen Y, Crawford JJ, Durk MR, Higuchi RI, Kang J, Murray J, Paraselli P, Park S, Phung W, Quinn JG, Roberts TC, Rougé L, Schwarz JB, Skippington E, Wai J, Xu M, Yu Z, Zhang H, Tan MW, Heise CE. Smith PA, et al. Among authors: xu m. Nature. 2018 Sep;561(7722):189-194. doi: 10.1038/s41586-018-0483-6. Epub 2018 Sep 12. Nature. 2018. PMID: 30209367
Structure of the essential inner membrane lipopolysaccharide-PbgA complex.
Clairfeuille T, Buchholz KR, Li Q, Verschueren E, Liu P, Sangaraju D, Park S, Noland CL, Storek KM, Nickerson NN, Martin L, Dela Vega T, Miu A, Reeder J, Ruiz-Gonzalez M, Swem D, Han G, DePonte DP, Hunter MS, Gati C, Shahidi-Latham S, Xu M, Skelton N, Sellers BD, Skippington E, Sandoval W, Hanan EJ, Payandeh J, Rutherford ST. Clairfeuille T, et al. Among authors: xu m. Nature. 2020 Aug;584(7821):479-483. doi: 10.1038/s41586-020-2597-x. Epub 2020 Aug 12. Nature. 2020. PMID: 32788728
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