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Bithionol eliminates acute myeloid leukaemia stem-like cells by suppressing NF-κB signalling and inducing oxidative stress, leading to apoptosis and ferroptosis.
Dias IRSB, Costa RGA, Rodrigues ACBDC, Silva SLR, Oliveira MS, Soares MBP, Dias RB, Valverde LF, Gurgel Rocha CA, Cairns LV, Mills KI, Bezerra DP. Dias IRSB, et al. Cell Death Discov. 2024 Aug 29;10(1):390. doi: 10.1038/s41420-024-02148-3. Cell Death Discov. 2024. PMID: 39209810 Free PMC article.
Cell signaling pathways as molecular targets to eliminate AML stem cells.
Rodrigues ACBDC, Costa RGA, Silva SLR, Dias IRSB, Dias RB, Bezerra DP. Rodrigues ACBDC, et al. Among authors: dias irsb. Crit Rev Oncol Hematol. 2021 Apr;160:103277. doi: 10.1016/j.critrevonc.2021.103277. Epub 2021 Mar 11. Crit Rev Oncol Hematol. 2021. PMID: 33716201 Review.