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Page 1
Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity.
Graboski AL, Simpson JB, Pellock SJ, Mehta N, Creekmore BC, Ariyarathna Y, Bhatt AP, Jariwala PB, Sekela JJ, Kowalewski ME, Barker NK, Mordant AL, Borlandelli VB, Overkleeft H, Herring LE, Jin J, I James L, Redinbo MR. Graboski AL, et al. RSC Chem Biol. 2024 Jul 16;5(9):853-865. doi: 10.1039/d4cb00058g. eCollection 2024 Aug 28. RSC Chem Biol. 2024. PMID: 39211470 Free PMC article.
Gut-Derived Protein-Bound Uremic Toxins.
Graboski AL, Redinbo MR. Graboski AL, et al. Toxins (Basel). 2020 Sep 11;12(9):590. doi: 10.3390/toxins12090590. Toxins (Basel). 2020. PMID: 32932981 Free PMC article. Review.
Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate.
Simpson JB, Sekela JJ, Graboski AL, Borlandelli VB, Bivins MM, Barker NK, Sorgen AA, Mordant AL, Johnson RL, Bhatt AP, Fodor AA, Herring LE, Overkleeft H, Lee JR, Redinbo MR. Simpson JB, et al. Among authors: graboski al. Gut Microbes. 2022 Jan-Dec;14(1):2107289. doi: 10.1080/19490976.2022.2107289. Gut Microbes. 2022. PMID: 35953888 Free PMC article.
Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.
Simpson JB, Walker ME, Sekela JJ, Ivey SM, Jariwala PB, Storch CM, Kowalewski ME, Graboski AL, Lietzan AD, Walton WG, Davis KA, Cloer EW, Borlandelli V, Hsiao YC, Roberts LR, Perlman DH, Liang X, Overkleeft HS, Bhatt AP, Lu K, Redinbo MR. Simpson JB, et al. Among authors: graboski al. Cell Host Microbe. 2024 Jun 12;32(6):925-944.e10. doi: 10.1016/j.chom.2024.04.018. Epub 2024 May 15. Cell Host Microbe. 2024. PMID: 38754417 Free article.
Discovery of CHD1 Antagonists for PTEN-Deficient Prostate Cancer.
Johnson RL, Graboski AL, Li F, Norris-Drouin JL, Walton WG, Arrowsmith CH, Redinbo MR, Frye SV, James LI. Johnson RL, et al. Among authors: graboski al. J Med Chem. 2024 Nov 28;67(22):20056-20075. doi: 10.1021/acs.jmedchem.4c01172. Epub 2024 Nov 7. J Med Chem. 2024. PMID: 39508435
Nanoparticle Delivery of miR-122 Inhibits Colorectal Cancer Liver Metastasis.
Sendi H, Yazdimamaghani M, Hu M, Sultanpuram N, Wang J, Moody AS, McCabe E, Zhang J, Graboski A, Li L, Rojas JD, Dayton PA, Huang L, Wang AZ. Sendi H, et al. Cancer Res. 2022 Jan 1;82(1):105-113. doi: 10.1158/0008-5472.CAN-21-2269. Epub 2021 Nov 9. Cancer Res. 2022. PMID: 34753773 Free PMC article.
Structure-Activity Relationship Studies of Acetazolamide-Based Carbonic Anhydrase Inhibitors with Activity against Neisseria gonorrhoeae.
Hewitt CS, Abutaleb NS, Elhassanny AEM, Nocentini A, Cao X, Amos DP, Youse MS, Holly KJ, Marapaka AK, An W, Kaur J, Krabill AD, Elkashif A, Elgammal Y, Graboski AL, Supuran CT, Seleem MN, Flaherty DP. Hewitt CS, et al. Among authors: graboski al. ACS Infect Dis. 2021 Jul 9;7(7):1969-1984. doi: 10.1021/acsinfecdis.1c00055. Epub 2021 Mar 25. ACS Infect Dis. 2021. PMID: 33765392 Free PMC article.