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Page 1
Advanced piperazine-containing inhibitors target microbial β-glucuronidases linked to gut toxicity.
Graboski AL, Simpson JB, Pellock SJ, Mehta N, Creekmore BC, Ariyarathna Y, Bhatt AP, Jariwala PB, Sekela JJ, Kowalewski ME, Barker NK, Mordant AL, Borlandelli VB, Overkleeft H, Herring LE, Jin J, I James L, Redinbo MR. Graboski AL, et al. Among authors: jariwala pb. RSC Chem Biol. 2024 Jul 16;5(9):853-865. doi: 10.1039/d4cb00058g. eCollection 2024 Aug 28. RSC Chem Biol. 2024. PMID: 39211470 Free PMC article.
Gut microbial β-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.
Simpson JB, Walker ME, Sekela JJ, Ivey SM, Jariwala PB, Storch CM, Kowalewski ME, Graboski AL, Lietzan AD, Walton WG, Davis KA, Cloer EW, Borlandelli V, Hsiao YC, Roberts LR, Perlman DH, Liang X, Overkleeft HS, Bhatt AP, Lu K, Redinbo MR. Simpson JB, et al. Among authors: jariwala pb. Cell Host Microbe. 2024 Jun 12;32(6):925-944.e10. doi: 10.1016/j.chom.2024.04.018. Epub 2024 May 15. Cell Host Microbe. 2024. PMID: 38754417 Free article.
Microbial β-glucuronidases drive human periodontal disease etiology.
Lietzan AD, Simpson JB, Walton WG, Jariwala PB, Xu Y, Boynton MH, Liu J, Redinbo MR. Lietzan AD, et al. Among authors: jariwala pb. Sci Adv. 2023 May 5;9(18):eadg3390. doi: 10.1126/sciadv.adg3390. Epub 2023 May 5. Sci Adv. 2023. PMID: 37146137 Free PMC article.
Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract.
Zhang J, Walker ME, Sanidad KZ, Zhang H, Liang Y, Zhao E, Chacon-Vargas K, Yeliseyev V, Parsonnet J, Haggerty TD, Wang G, Simpson JB, Jariwala PB, Beaty VV, Yang J, Yang H, Panigrahy A, Minter LM, Kim D, Gibbons JG, Liu L, Li Z, Xiao H, Borlandelli V, Overkleeft HS, Cloer EW, Major MB, Goldfarb D, Cai Z, Redinbo MR, Zhang G. Zhang J, et al. Among authors: jariwala pb. Nat Commun. 2022 Jan 10;13(1):136. doi: 10.1038/s41467-021-27762-y. Nat Commun. 2022. PMID: 35013263 Free PMC article.