Li N - Search Results

1

Distinct chemical degradation pathways of AAV1 and AAV8 under thermal stress conditions revealed by analytical anion exchange chromatography and LC-MS-based peptide mapping.

Xing T, Li S, Tang S, Huang Y, Liu G, Yan Y, Liu D, Wang S, Zhi L, Shameem M, Li N. Xing T, et al. Among authors: li s, li n. J Pharm Biomed Anal. 2024 Dec 15;251:116452. doi: 10.1016/j.jpba.2024.116452. Epub 2024 Aug 26. J Pharm Biomed Anal. 2024. PMID: 39217700 Free article.

2

Ultrasensitive Characterization of Charge Heterogeneity of Therapeutic Monoclonal Antibodies Using Strong Cation Exchange Chromatography Coupled to Native Mass Spectrometry.

Yan Y, Liu AP, Wang S, Daly TJ, Li N. Yan Y, et al. Among authors: li n. Anal Chem. 2018 Nov 6;90(21):13013-13020. doi: 10.1021/acs.analchem.8b03773. Epub 2018 Oct 18. Anal Chem. 2018. PMID: 30280893 Free article.

3

Simple Approach for Improved LC-MS Analysis of Protein Biopharmaceuticals via Modification of Desolvation Gas.

Wang S, Xing T, Liu AP, He Z, Yan Y, Daly TJ, Li N. Wang S, et al. Among authors: li n. Anal Chem. 2019 Feb 19;91(4):3156-3162. doi: 10.1021/acs.analchem.8b05846. Epub 2019 Feb 7. Anal Chem. 2019. PMID: 30682238 Free article.

4

Coupling Mixed-Mode Size Exclusion Chromatography with Native Mass Spectrometry for Sensitive Detection and Quantitation of Homodimer Impurities in Bispecific IgG.

Yan Y, Xing T, Wang S, Daly TJ, Li N. Yan Y, et al. Among authors: li n. Anal Chem. 2019 Sep 3;91(17):11417-11424. doi: 10.1021/acs.analchem.9b02793. Epub 2019 Aug 15. Anal Chem. 2019. PMID: 31373790 Free article.

5

Quantitation and modeling of post-translational modifications in a therapeutic monoclonal antibody from single- and multiple-dose monkey pharmacokinetic studies using mass spectrometry.

Xu X, Huang Y, Pan H, Molden R, Qiu H, Daly TJ, Li N. Xu X, et al. Among authors: li n. PLoS One. 2019 Oct 16;14(10):e0223899. doi: 10.1371/journal.pone.0223899. eCollection 2019. PLoS One. 2019. PMID: 31618250 Free PMC article.

6

Online coupling of analytical hydrophobic interaction chromatography with native mass spectrometry for the characterization of monoclonal antibodies and related products.

Yan Y, Xing T, Wang S, Daly TJ, Li N. Yan Y, et al. Among authors: li n. J Pharm Biomed Anal. 2020 Jul 15;186:113313. doi: 10.1016/j.jpba.2020.113313. Epub 2020 Apr 20. J Pharm Biomed Anal. 2020. PMID: 32371326 Free article.

7

An ¹⁸O-Labeling Assisted LC-MS Method for Accurate Quantitation of Unprocessed C-Terminal Lysine in Therapeutic Monoclonal Antibodies.

Wang S, Liu AP, Li N. Wang S, et al. Among authors: li n. J Am Soc Mass Spectrom. 2020 Jul 1;31(7):1587-1592. doi: 10.1021/jasms.0c00149. Epub 2020 Jun 23. J Am Soc Mass Spectrom. 2020. PMID: 32515589

8

Characterization of Adeno-Associated Virus Capsid Proteins Using Hydrophilic Interaction Chromatography Coupled with Mass Spectrometry.

Liu AP, Patel SK, Xing T, Yan Y, Wang S, Li N. Liu AP, et al. Among authors: li n. J Pharm Biomed Anal. 2020 Sep 10;189:113481. doi: 10.1016/j.jpba.2020.113481. Epub 2020 Jul 21. J Pharm Biomed Anal. 2020. PMID: 32750536 Free article.

9

Versatile, Sensitive, and Robust Native LC-MS Platform for Intact Mass Analysis of Protein Drugs.

Yan Y, Xing T, Wang S, Li N. Yan Y, et al. Among authors: li n. J Am Soc Mass Spectrom. 2020 Oct 7;31(10):2171-2179. doi: 10.1021/jasms.0c00277. Epub 2020 Sep 11. J Am Soc Mass Spectrom. 2020. PMID: 32865416

10

Integration of liquid chromatography mass spectrometry with a heavy peptide response curve accurately measures unprocessed C-terminal lysine during peptide mapping analysis of therapeutic antibodies in a single run.

Greer T, O'Brien Johnson R, Cejkov M, Zheng X, Li N. Greer T, et al. Among authors: li n. J Pharm Biomed Anal. 2021 Apr 15;197:113963. doi: 10.1016/j.jpba.2021.113963. Epub 2021 Feb 12. J Pharm Biomed Anal. 2021. PMID: 33626446

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