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Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α-Glucosidase II Inhibitor, Blocks Replication of SARS-CoV-2 and Other Coronaviruses.
Thaler M, Ofman TP, Kok K, Heming JJA, Moran E, Pickles I, Leijs AA, van den Nieuwendijk AMCH, van den Berg RJBHN, Ruijgrok G, Armstrong Z, Salgado-Benvindo C, Ninaber DK, Snijder EJ, van Boeckel CAA, Artola M, Davies GJ, Overkleeft HS, van Hemert MJ. Thaler M, et al. Among authors: kok k. ACS Cent Sci. 2024 Jul 25;10(8):1594-1608. doi: 10.1021/acscentsci.4c00506. eCollection 2024 Aug 28. ACS Cent Sci. 2024. PMID: 39220688 Free PMC article.
Conformational and Electronic Variations in 1,2- and 1,5a-Cyclophellitols and their Impact on Retaining α-Glucosidase Inhibition.
Ofman TP, Heming JJA, Nin-Hill A, Küllmer F, Moran E, Bennett M, Steneker R, Klein AM, Ruijgrok G, Kok K, Armstrong ZWB, Aerts JMFG, van der Marel GA, Rovira C, Davies GJ, Artola M, Codée JDC, Overkleeft HS. Ofman TP, et al. Among authors: kok k. Chemistry. 2024 Jun 3;30(31):e202400723. doi: 10.1002/chem.202400723. Epub 2024 Apr 24. Chemistry. 2024. PMID: 38623783
Trans-cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 α-d-mannosidases through a bump-hole strategy.
Males A, Kok K, Nin-Hill A, de Koster N, van den Beukel S, Beenakker TJM, van der Marel GA, Codée JDC, Aerts JMFG, Overkleeft HS, Rovira C, Davies GJ, Artola M. Males A, et al. Among authors: kok k. Chem Sci. 2023 Nov 17;14(46):13581-13586. doi: 10.1039/d3sc05016e. eCollection 2023 Nov 29. Chem Sci. 2023. PMID: 38033892 Free PMC article.
435 results