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Page 1
Adipose stem cells are sexually dimorphic cells with dual roles as preadipocytes and resident fibroblasts.
Uhrbom M, Muhl L, Genové G, Liu J, Palmgren H, Alexandersson I, Karlsson F, Zhou AX, Lunnerdal S, Gustafsson S, Buyandelger B, Petkevicius K, Ahlstedt I, Karlsson D, Aasehaug L, He L, Jeansson M, Betsholtz C, Peng XR. Uhrbom M, et al. Among authors: alexandersson i. Nat Commun. 2024 Sep 2;15(1):7643. doi: 10.1038/s41467-024-51867-9. Nat Commun. 2024. PMID: 39223126 Free PMC article.
Cellular senescence in hepatocytes contributes to metabolic disturbances in NASH.
Bonnet L, Alexandersson I, Baboota RK, Kroon T, Oscarsson J, Smith U, Boucher J. Bonnet L, et al. Among authors: alexandersson i. Front Endocrinol (Lausanne). 2022 Aug 22;13:957616. doi: 10.3389/fendo.2022.957616. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36072934 Free PMC article.
Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce.
Li Q, Hagberg CE, Silva Cascales H, Lang S, Hyvönen MT, Salehzadeh F, Chen P, Alexandersson I, Terezaki E, Harms MJ, Kutschke M, Arifen N, Krämer N, Aouadi M, Knibbe C, Boucher J, Thorell A, Spalding KL. Li Q, et al. Among authors: alexandersson i. Nat Med. 2021 Nov;27(11):1941-1953. doi: 10.1038/s41591-021-01501-8. Epub 2021 Oct 4. Nat Med. 2021. PMID: 34608330
PPARγ and PPARα synergize to induce robust browning of white fat in vivo.
Kroon T, Harms M, Maurer S, Bonnet L, Alexandersson I, Lindblom A, Ahnmark A, Nilsson D, Gennemark P, O'Mahony G, Osinski V, McNamara C, Boucher J. Kroon T, et al. Among authors: alexandersson i. Mol Metab. 2020 Jun;36:100964. doi: 10.1016/j.molmet.2020.02.007. Epub 2020 Feb 18. Mol Metab. 2020. PMID: 32248079 Free PMC article.