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Prediction of homologous recombination deficiency from routine histology with attention-based multiple instance learning in nine different tumor types.
Loeffler CML, El Nahhas OSM, Muti HS, Carrero ZI, Seibel T, van Treeck M, Cifci D, Gustav M, Bretz K, Gaisa NT, Lehmann KV, Leary A, Selenica P, Reis-Filho JS, Ortiz-Bruechle N, Kather JN. Loeffler CML, et al. Among authors: selenica p. BMC Biol. 2024 Oct 8;22(1):225. doi: 10.1186/s12915-024-02022-9. BMC Biol. 2024. PMID: 39379982 Free PMC article.
RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability.
Jalan M, Sharma A, Pei X, Weinhold N, Buechelmaier ES, Zhu Y, Ahmed-Seghir S, Ratnakumar A, Di Bona M, McDermott N, Gomez-Aguilar J, Anderson KS, Ng CKY, Selenica P, Bakhoum SF, Reis-Filho JS, Riaz N, Powell SN. Jalan M, et al. Among authors: selenica p. Nat Commun. 2024 Sep 5;15(1):7776. doi: 10.1038/s41467-024-51784-x. Nat Commun. 2024. PMID: 39237529 Free PMC article.
Large-scale copy number alterations are enriched for synthetic viability in BRCA1/BRCA2 tumors.
Zhu Y, Pei X, Novaj A, Setton J, Bronder D, Derakhshan F, Selenica P, McDermott N, Orman M, Plum S, Subramanyan S, Braverman SH, McMillan B, Sinha S, Ma J, Gazzo A, Khan A, Bakhoum S, Powell SN, Reis-Filho JS, Riaz N. Zhu Y, et al. Among authors: selenica p. Genome Med. 2024 Aug 28;16(1):108. doi: 10.1186/s13073-024-01371-y. Genome Med. 2024. PMID: 39198848 Free PMC article.
Chromothripsis-mediated small cell lung carcinoma.
Rekhtman N, Tischfield SE, Febres-Aldana CA, Lee JJ, Chang JC, Herzberg BO, Selenica P, Woo HJ, Vanderbilt CM, Yang SR, Xu F, Bowman AS, da Silva EM, Noronha AM, Mandelker DL, Mehine M, Mukherjee S, Blanco-Heredia J, Orgera JJ, Nanjangud GJ, Baine MK, Aly RG, Sauter JL, Travis WD, Savari O, Moreira AL, Falcon CJ, Bodd FM, Wilson CE, Sienty JV, Manoj P, Sridhar H, Wang L, Choudhury NJ, Offin M, Yu HA, Quintanal-Villalonga A, Berger MF, Ladanyi M, Donoghue MTA, Reis-Filho JS, Rudin CM. Rekhtman N, et al. Among authors: selenica p. Cancer Discov. 2024 Aug 26. doi: 10.1158/2159-8290.CD-24-0286. Online ahead of print. Cancer Discov. 2024. PMID: 39185963
A Genomics-Driven Artificial Intelligence-Based Model Classifies Breast Invasive Lobular Carcinoma and Discovers CDH1 Inactivating Mechanisms.
Pareja F, Dopeso H, Wang YK, Gazzo AM, Brown DN, Banerjee M, Selenica P, Bernhard JH, Derakhshan F, da Silva EM, Colon-Cartagena L, Basili T, Marra A, Sue J, Ye Q, Da Cruz Paula A, Yeni Yildirim S, Pei X, Safonov A, Green H, Gill KY, Zhu Y, Lee MCH, Godrich RA, Casson A, Weigelt B, Riaz N, Wen HY, Brogi E, Mandelker DL, Hanna MG, Kunz JD, Rothrock B, Chandarlapaty S, Kanan C, Oakley J, Klimstra DS, Fuchs TJ, Reis-Filho JS. Pareja F, et al. Among authors: selenica p. Cancer Res. 2024 Oct 15;84(20):3478-3489. doi: 10.1158/0008-5472.CAN-24-1322. Cancer Res. 2024. PMID: 39106449
Spatial molecular profiling of mixed invasive ductal and lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations.
Shah OS, Nasrazadani A, Foldi J, Atkinson JM, Kleer CG, McAuliffe PF, Johnston TJ, Stallaert W, da Silva EM, Selenica P, Dopeso H, Pareja F, Mandelker D, Weigelt B, Reis-Filho JS, Bhargava R, Lucas PC, Lee AV, Oesterreich S. Shah OS, et al. Among authors: selenica p. Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2322068121. doi: 10.1073/pnas.2322068121. Epub 2024 Jul 23. Proc Natl Acad Sci U S A. 2024. PMID: 39042692
ERBB2 mutations define a subgroup of endometrial carcinomas associated with high tumor mutational burden and the microsatellite instability-high (MSI-H) molecular subtype.
Brodeur MN, Selenica P, Ma W, Moufarrij S, Dagher C, Basili T, Abu-Rustum NR, Aghajanian C, Zhou Q, Iasonos A, Ellenson LH, Weigelt B, Chui MH. Brodeur MN, et al. Among authors: selenica p. Mol Oncol. 2024 Oct;18(10):2356-2368. doi: 10.1002/1878-0261.13698. Epub 2024 Jul 19. Mol Oncol. 2024. PMID: 39031567 Free PMC article.
Increased Synthetic Cytotoxicity of Combinatorial Chemoradiation Therapy in Homologous Recombination Deficient Tumors.
Ma J, Shah R, Bell AC, McDermott N, Pei X, Selenica P, Haseltine J, Delsite R, Khan AJ, Lok BH, Ellis MJ, Aft RF, Setton J, Reis-Filho JS, Riaz N, Powell SN. Ma J, et al. Among authors: selenica p. Int J Radiat Oncol Biol Phys. 2024 Jul 10:S0360-3016(24)02946-8. doi: 10.1016/j.ijrobp.2024.06.037. Online ahead of print. Int J Radiat Oncol Biol Phys. 2024. PMID: 38997095
113 results