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An expeditious synthesis of tamoxifen, a representative SERM (selective estrogen receptor modulator), via the three-component coupling reaction among aromatic aldehyde, cinnamyltrimethylsilane, and beta-chlorophenetole.
Shiina I, Sano Y, Nakata K, Suzuki M, Yokoyama T, Sasaki A, Orikasa T, Miyamoto T, Ikekita M, Nagahara Y, Hasome Y. Shiina I, et al. Bioorg Med Chem. 2007 Dec 15;15(24):7599-617. doi: 10.1016/j.bmc.2007.09.008. Epub 2007 Sep 12. Bioorg Med Chem. 2007. PMID: 17904372
Novel tamoxifen derivative Ridaifen-B induces Bcl-2 independent autophagy without estrogen receptor involvement.
Nagahara Y, Takeyoshi M, Sakemoto S, Shiina I, Nakata K, Fujimori K, Wang Y, Umeda E, Watanabe C, Uetake S, Yamori T, Dan S, Yoshimi Y, Shinomiya T, Ikekita M. Nagahara Y, et al. Among authors: shiina i. Biochem Biophys Res Commun. 2013 Jun 14;435(4):657-63. doi: 10.1016/j.bbrc.2013.05.040. Epub 2013 May 18. Biochem Biophys Res Commun. 2013. PMID: 23688426
Anti-proliferative effect of ridaifen-B on hepatoma cells.
Hasegawa G, Akatsuka K, Hiruma K, Suda K, Yokoe Y, Mizusawa A, Ota N, Shibata N, Tsuchiya K, Hayashi M, Shiina I, Shimonaka M. Hasegawa G, et al. Among authors: shiina i. Biomed Rep. 2018 Aug;9(2):175-180. doi: 10.3892/br.2018.1112. Epub 2018 Jun 13. Biomed Rep. 2018. PMID: 30013780 Free PMC article.
79 results