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Molecular characterisation of influenza B virus from the 2017/18 season in primary models of the human lung reveals improved adaptation to the lower respiratory tract.
Çalışkan DM, Kumar S, Hinse S, Schughart K, Wiewrodt R, Fischer S, Krueger V, Wiebe K, Barth P, Mellmann A, Ludwig S, Brunotte L. Çalışkan DM, et al. Among authors: brunotte l. Emerg Microbes Infect. 2024 Dec;13(1):2402868. doi: 10.1080/22221751.2024.2402868. Epub 2024 Sep 23. Emerg Microbes Infect. 2024. PMID: 39248230 Free PMC article.
Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA.
Kleinehr J, Schöfbänker M, Daniel K, Günl F, Mohamed FF, Janowski J, Brunotte L, Boergeling Y, Liebmann M, Behrens M, Gerdemann A, Klotz L, Esselen M, Humpf HU, Ludwig S, Hrincius ER. Kleinehr J, et al. Among authors: brunotte l. PLoS Pathog. 2023 Jul 13;19(7):e1010986. doi: 10.1371/journal.ppat.1010986. eCollection 2023 Jul. PLoS Pathog. 2023. PMID: 37440521 Free PMC article.
Cell-intrinsic genomic reassortment of pandemic H1N1 2009 and Eurasian avian-like swine influenza viruses results in potentially zoonotic variants.
Ferrando VA, Friedrich ME, Gandhi S, Mellmann A, Masemann D, Christersson A, Anhlan D, Brunotte L, Stoll M, Harder T, Beer M, Boergeling Y, Ludwig S. Ferrando VA, et al. Among authors: brunotte l. Emerg Microbes Infect. 2023 Dec;12(1):2212809. doi: 10.1080/22221751.2023.2212809. Emerg Microbes Infect. 2023. PMID: 37191590 Free PMC article.
The ubiquitination landscape of the influenza A virus polymerase.
Günl F, Krischuns T, Schreiber JA, Henschel L, Wahrenburg M, Drexler HCA, Leidel SA, Cojocaru V, Seebohm G, Mellmann A, Schwemmle M, Ludwig S, Brunotte L. Günl F, et al. Among authors: brunotte l. Nat Commun. 2023 Feb 11;14(1):787. doi: 10.1038/s41467-023-36389-0. Nat Commun. 2023. PMID: 36774438 Free PMC article.
Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication.
Tsukamoto Y, Hiono T, Yamada S, Matsuno K, Faist A, Claff T, Hou J, Namasivayam V, Vom Hemdt A, Sugimoto S, Ng JY, Christensen MH, Tesfamariam YM, Wolter S, Juranek S, Zillinger T, Bauer S, Hirokawa T, Schmidt FI, Kochs G, Shimojima M, Huang YS, Pichlmair A, Kümmerer BM, Sakoda Y, Schlee M, Brunotte L, Müller CE, Igarashi M, Kato H. Tsukamoto Y, et al. Among authors: brunotte l. Science. 2023 Feb 10;379(6632):586-591. doi: 10.1126/science.add0875. Epub 2023 Feb 9. Science. 2023. PMID: 36758070
Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier.
Faist A, Schloer S, Mecate-Zambrano A, Janowski J, Schreiber A, Boergeling Y, Conrad BCG, Kumar S, Toebben L, Schughart K, Baumgardt M, Kessler M, Hoenzke K, Hocke A, Trautmann M, Hartmann W, Kato H, Rescher U, Christersson A, Kuehn J, Mellmann A, Wolff T, Kuempers P, Rovas A, Wiewrodt R, Wiebe K, Barth P, Ludwig S, Brunotte L. Faist A, et al. Among authors: brunotte l. Antiviral Res. 2023 Jan;209:105475. doi: 10.1016/j.antiviral.2022.105475. Epub 2022 Nov 21. Antiviral Res. 2023. PMID: 36423831 Free PMC article.
3D Ex vivo tissue platforms to investigate the early phases of influenza a virus- and SARS-CoV-2-induced respiratory diseases.
Schloer S, Treuherz D, Faist A, de Witt M, Wunderlich K, Wiewrodt R, Wiebe K, Barth P, Wälzlein JH, Kummer S, Balkema-Buschmann A, Ludwig S, Brunotte L, Rescher U. Schloer S, et al. Among authors: brunotte l. Emerg Microbes Infect. 2022 Dec;11(1):2160-2175. doi: 10.1080/22221751.2022.2117101. Emerg Microbes Infect. 2022. PMID: 36000328 Free PMC article.
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke K, Obermayer B, Mache C, Fatykhova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, Mecate-Zambrano A, Bushe J, Dohmen M, Hinze C, Elezkurtaj S, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Schmidt-Ott KM, Busch J, Klauschen F, Horst D, Radbruch H, Radke J, Heppner F, Corman VM, Niemeyer D, Müller MA, Goffinet C, Mothes R, Pascual-Reguant A, Hauser AE, Beule D, Landthaler M, Ludwig S, Suttorp N, Witzenrath M, Gruber AD, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC. Hönzke K, et al. Among authors: brunotte l. Eur Respir J. 2022 Dec 1;60(6):2102725. doi: 10.1183/13993003.02725-2021. Print 2022 Dec. Eur Respir J. 2022. PMID: 35728978 Free PMC article.
41 results