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Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response.
Germeys C, Vandoorne T, Davie K, Poovathingal S, Heeren K, Vermeire W, Nami F, Moisse M, Quaegebeur A, Sierksma A, Rué L, Sicart A, Eykens C, De Cock L, De Strooper B, Carmeliet P, Van Damme P, De Bock K, Van Den Bosch L. Germeys C, et al. Among authors: vandoorne t. Cell Rep. 2024 Sep 24;43(9):114719. doi: 10.1016/j.celrep.2024.114719. Epub 2024 Sep 9. Cell Rep. 2024. PMID: 39255062 Free article.
Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition.
Stoklund Dittlau K, Krasnow EN, Fumagalli L, Vandoorne T, Baatsen P, Kerstens A, Giacomazzi G, Pavie B, Rossaert E, Beckers J, Sampaolesi M, Van Damme P, Van Den Bosch L. Stoklund Dittlau K, et al. Among authors: vandoorne t. Stem Cell Reports. 2021 Sep 14;16(9):2213-2227. doi: 10.1016/j.stemcr.2021.03.029. Epub 2021 Apr 22. Stem Cell Reports. 2021. PMID: 33891869 Free PMC article.
C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility.
Fumagalli L, Young FL, Boeynaems S, De Decker M, Mehta AR, Swijsen A, Fazal R, Guo W, Moisse M, Beckers J, Dedeene L, Selvaraj BT, Vandoorne T, Madan V, van Blitterswijk M, Raitcheva D, McCampbell A, Poesen K, Gitler AD, Koch P, Vanden Berghe P, Thal DR, Verfaillie C, Chandran S, Van Den Bosch L, Bullock SL, Van Damme P. Fumagalli L, et al. Among authors: vandoorne t. Sci Adv. 2021 Apr 9;7(15):eabg3013. doi: 10.1126/sciadv.abg3013. Print 2021 Apr. Sci Adv. 2021. PMID: 33837088 Free PMC article.
HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations.
Fazal R, Boeynaems S, Swijsen A, De Decker M, Fumagalli L, Moisse M, Vanneste J, Guo W, Boon R, Vercruysse T, Eggermont K, Swinnen B, Beckers J, Pakravan D, Vandoorne T, Vanden Berghe P, Verfaillie C, Van Den Bosch L, Van Damme P. Fazal R, et al. Among authors: vandoorne t. EMBO J. 2021 Apr 1;40(7):e106177. doi: 10.15252/embj.2020106177. Epub 2021 Mar 10. EMBO J. 2021. PMID: 33694180 Free PMC article.
Existing and Emerging Metabolomic Tools for ALS Research.
Germeys C, Vandoorne T, Bercier V, Van Den Bosch L. Germeys C, et al. Among authors: vandoorne t. Genes (Basel). 2019 Dec 5;10(12):1011. doi: 10.3390/genes10121011. Genes (Basel). 2019. PMID: 31817338 Free PMC article. Review.
Differentiation but not ALS mutations in FUS rewires motor neuron metabolism.
Vandoorne T, Veys K, Guo W, Sicart A, Vints K, Swijsen A, Moisse M, Eelen G, Gounko NV, Fumagalli L, Fazal R, Germeys C, Quaegebeur A, Fendt SM, Carmeliet P, Verfaillie C, Van Damme P, Ghesquière B, De Bock K, Van Den Bosch L. Vandoorne T, et al. Nat Commun. 2019 Sep 12;10(1):4147. doi: 10.1038/s41467-019-12099-4. Nat Commun. 2019. PMID: 31515480 Free PMC article.
Energy metabolism in ALS: an underappreciated opportunity?
Vandoorne T, De Bock K, Van Den Bosch L. Vandoorne T, et al. Acta Neuropathol. 2018 Apr;135(4):489-509. doi: 10.1007/s00401-018-1835-x. Epub 2018 Mar 16. Acta Neuropathol. 2018. PMID: 29549424 Free PMC article. Review.
13 results