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Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH).
Sundararaman SA, Miller JJ, Daley EC, O'Brien KA, Kasak P, Daniels AM, Edwards RL, Heidel KM, Bague DA, Wilson MA, Koelper AJ, Kourtoglou EC, White AD, August SA, Apple GA, Rouamba RW, Durand AJ, Esteb JJ, Muller FL, Johnson RJ, Hoops GC, Dowd CS, Odom John AR. Sundararaman SA, et al. Among authors: miller jj. bioRxiv [Preprint]. 2024 Aug 31:2024.08.30.610542. doi: 10.1101/2024.08.30.610542. bioRxiv. 2024. PMID: 39257815 Free PMC article. Preprint.
Potent, specific MEPicides for treatment of zoonotic staphylococci.
Edwards RL, Heueck I, Lee SG, Shah IT, Miller JJ, Jezewski AJ, Mikati MO, Wang X, Brothers RC, Heidel KM, Osbourn DM, Burnham CD, Alvarez S, Fritz SA, Dowd CS, Jez JM, Odom John AR. Edwards RL, et al. Among authors: miller jj. PLoS Pathog. 2020 Jun 4;16(6):e1007806. doi: 10.1371/journal.ppat.1007806. eCollection 2020 Jun. PLoS Pathog. 2020. PMID: 32497104 Free PMC article.
Antimicrobial Prodrug Activation by the Staphylococcal Glyoxalase GloB.
Mikati MO, Miller JJ, Osbourn DM, Barekatain Y, Ghebremichael N, Shah IT, Burnham CD, Heidel KM, Yan VC, Muller FL, Dowd CS, Edwards RL, Odom John AR. Mikati MO, et al. Among authors: miller jj. ACS Infect Dis. 2020 Nov 13;6(11):3064-3075. doi: 10.1021/acsinfecdis.0c00582. Epub 2020 Oct 29. ACS Infect Dis. 2020. PMID: 33118347 Free PMC article.
Structure-guided microbial targeting of antistaphylococcal prodrugs.
Miller JJ, Shah IT, Hatten J, Barekatain Y, Mueller EA, Moustafa AM, Edwards RL, Dowd CS, Hoops GC, Johnson RJ, Planet PJ, Muller FL, Jez JM, Odom John AR. Miller JJ, et al. Elife. 2021 Jul 19;10:e66657. doi: 10.7554/eLife.66657. Elife. 2021. PMID: 34279224 Free PMC article.
Accounting for fast vs slow exchange in single molecule FRET experiments reveals hidden conformational states.
Miller JJ, Mallimadugula UL, Zimmerman MI, Stuchell-Brereton MD, Soranno A, Bowman GR. Miller JJ, et al. bioRxiv [Preprint]. 2024 Jun 3:2024.06.03.597137. doi: 10.1101/2024.06.03.597137. bioRxiv. 2024. Update in: J Chem Theory Comput. 2024 Dec 10;20(23):10339-10349. doi: 10.1021/acs.jctc.4c01068 PMID: 38895430 Free PMC article. Updated. Preprint.
The G protein inhibitor YM-254890 is an allosteric glue.
Trent T, Miller JJ, Bowman GR. Trent T, et al. Among authors: miller jj. bioRxiv [Preprint]. 2024 Nov 28:2024.11.25.625299. doi: 10.1101/2024.11.25.625299. bioRxiv. 2024. PMID: 39651278 Free PMC article. Preprint.
666 results