Hernandez Bort JA - Search Results

1

Factors affecting rAAV titers during triple-plasmid transient transfection in HEK-293 cells.

Pistek M, Andorfer P, Grabherr R, Kraus B, Hernandez Bort JA. Pistek M, et al. Among authors: hernandez bort ja. Biotechnol Lett. 2024 Dec;46(6):945-959. doi: 10.1007/s10529-024-03520-0. Epub 2024 Sep 11. Biotechnol Lett. 2024. PMID: 39259435 Free PMC article.

2

Cas-CLOVER-mediated knockout of STAT1: A novel approach to engineer packaging HEK-293 cell lines used for rAAV production.

Andorfer P, Kahlig CI, Pakusic D, Pachlinger R, John C, Schrenk I, Eisenhut P, Lengler J, Innthaler B, Micutkova L, Kraus B, Brizzee C, Crawford J, Hernandez Bort JA. Andorfer P, et al. Among authors: hernandez bort ja. Biotechnol J. 2024 Sep;19(9):e2400415. doi: 10.1002/biot.202400415. Biotechnol J. 2024. PMID: 39246130

3

Orthogonal characterization of rAAV9 reveals unexpected transgene heterogeneity.

Eisenhut P, Andorfer P, Haid A, Jokl B, Manhartsberger R, Fuchsberger F, Innthaler B, Lengler J, Kraus B, Pletzenauer R, Hernandez Bort JA, Unterthurner S. Eisenhut P, et al. Among authors: hernandez bort ja. J Biotechnol. 2024 Sep 20;393:128-139. doi: 10.1016/j.jbiotec.2024.07.020. Epub 2024 Aug 4. J Biotechnol. 2024. PMID: 39106910 Free article.

4

Logistic PCA explains differences between genome-scale metabolic models in terms of metabolic pathways.

Zehetner L, Széliová D, Kraus B, Hernandez Bort JA, Zanghellini J. Zehetner L, et al. Among authors: hernandez bort ja. PLoS Comput Biol. 2024 Jun 24;20(6):e1012236. doi: 10.1371/journal.pcbi.1012236. eCollection 2024 Jun. PLoS Comput Biol. 2024. PMID: 38913731 Free PMC article.

5

Enhancement of rAAV titers via inhibition of the interferon signaling cascade in transfected HEK293 suspension cultures.

Kahlig CI, Moser S, Micutkova L, Grillari J, Kraus B, Hernandez Bort JA. Kahlig CI, et al. Among authors: hernandez bort ja. Biotechnol J. 2024 May;19(5):e2300672. doi: 10.1002/biot.202300672. Biotechnol J. 2024. PMID: 38719621

6

Scaling strategy for cell and gene therapy bioreactors based on turbulent parameters.

Iurashev D, Jones PA, Andreev N, Wang Y, Iwata-Kajihara T, Kraus B, Hernandez Bort JA. Iurashev D, et al. Among authors: hernandez bort ja. Biotechnol J. 2024 Jan;19(1):e2300235. doi: 10.1002/biot.202300235. Epub 2023 Nov 20. Biotechnol J. 2024. PMID: 37906704

7

Comprehensive mRNA-sequencing-based characterization of three HEK-293 cell lines during an rAAV production process for gene therapy applications.

Pistek M, Kahlig CI, Hackl M, Unterthurner S, Kraus B, Grabherr R, Grillari J, Hernandez Bort JA. Pistek M, et al. Among authors: hernandez bort ja. Biotechnol J. 2023 Aug;18(8):e2200513. doi: 10.1002/biot.202200513. Epub 2023 May 23. Biotechnol J. 2023. PMID: 37191240

8

Optimizing VLP production in gene therapy: Opportunities and challenges for in silico modeling.

Zehetner L, Széliová D, Kraus B, Graninger M, Zanghellini J, Hernandez Bort JA. Zehetner L, et al. Among authors: hernandez bort ja. Biotechnol J. 2023 Jul;18(7):e2200636. doi: 10.1002/biot.202200636. Epub 2023 May 13. Biotechnol J. 2023. PMID: 37129529 Review.

9

Assessment of the percentage of full recombinant adeno-associated virus particles in a gene therapy drug using CryoTEM.

Colomb-Delsuc M, Raim R, Fiedler C, Reuberger S, Lengler J, Nordström R, Ryner M, Folea IM, Kraus B, Hernandez Bort JA, Sintorn IM. Colomb-Delsuc M, et al. Among authors: hernandez bort ja. PLoS One. 2022 Jun 3;17(6):e0269139. doi: 10.1371/journal.pone.0269139. eCollection 2022. PLoS One. 2022. PMID: 35657790 Free PMC article.

10

Proton-transfer-reaction mass spectrometry (PTR-MS) for online monitoring of glucose depletion and cell concentrations in HEK 293 gene therapy processes.

Bayer B, Maccani A, Jahn J, Duerkop M, Kapeller E, Pletzenauer R, Kraus B, Striedner G, Hernandez Bort JA. Bayer B, et al. Among authors: hernandez bort ja. Biotechnol Lett. 2022 Jan;44(1):77-88. doi: 10.1007/s10529-021-03205-y. Epub 2021 Nov 12. Biotechnol Lett. 2022. PMID: 34767126 Free PMC article.

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