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Feasibility study for a downsized comparative thyroid assay with measurement of brain thyroid hormones and histopathology in rats: Case study with 6-propylthiouracil and sodium phenobarbital at high dose.
Minami K, Suto H, Sato A, Ogata K, Kosaka T, Hojo H, Takahashi N, Tomiyama N, Fukuda T, Iwashita K, Aoyama H, Yamada T. Minami K, et al. Among authors: sato a. Regul Toxicol Pharmacol. 2023 Jan;137:105283. doi: 10.1016/j.yrtph.2022.105283. Epub 2022 Nov 11. Regul Toxicol Pharmacol. 2023. PMID: 36372265
Prenatal test cohort of a modified rat comparative thyroid assay adding brain thyroid hormone measurements and histology but lowering group size appears able to detect disruption by sodium phenobarbital.
Minami K, Sato A, Tomiyama N, Ogata K, Kosaka T, Hojo H, Takahashi N, Suto H, Aoyama H, Yamada T. Minami K, et al. Among authors: sato a. Curr Res Toxicol. 2024 Apr 18;6:100168. doi: 10.1016/j.crtox.2024.100168. eCollection 2024. Curr Res Toxicol. 2024. PMID: 38693933 Free PMC article.
5,467 results