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Timeline to symptomatic Alzheimer's disease in people with Down syndrome as assessed by amyloid-PET and tau-PET: a longitudinal cohort study.
Schworer EK, Zammit MD, Wang J, Handen BL, Betthauser T, Laymon CM, Tudorascu DL, Cohen AD, Zaman SH, Ances BM, Mapstone M, Head E, Christian BT, Hartley SL; Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS). Schworer EK, et al. Lancet Neurol. 2024 Dec;23(12):1214-1224. doi: 10.1016/S1474-4422(24)00426-5. Lancet Neurol. 2024. PMID: 39577922
The effects of mosaicism on biological and clinical markers of Alzheimer's disease in adults with Down syndrome.
Xicota L, Dang LT, Lee A, Krinsky-McHale S, Pang D, Melilli L, O'Bryant S, Henson RL, Laymon C, Lai F, Rosas HD, Ances B, Lott I, Hom C, Christian B, Hartley S, Zaman S, Head E, Mapstone M, Jin Z, Silverman W, Schupf N, Handen B, Lee JH; Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS). Xicota L, et al. EBioMedicine. 2024 Dec;110:105433. doi: 10.1016/j.ebiom.2024.105433. Epub 2024 Nov 4. EBioMedicine. 2024. PMID: 39500037 Free PMC article.
Cerebrovascular disease is associated with Alzheimer's plasma biomarker concentrations in adults with Down syndrome.
Edwards NC, Lao PJ, Alshikho MJ, Ericsson OM, Rizvi B, Petersen ME, O'Bryant S, Aguilar LF, Simoes S, Mapstone M, Tudorascu DL, Janelidze S, Hansson O, Handen BL, Christian BT, Lee JH, Lai F, Rosas HD, Zaman S, Lott IT, Yassa MA; Alzheimer’s Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators; Gutierrez J, Wilcock DM, Head E, Brickman AM. Edwards NC, et al. Brain Commun. 2024 Sep 25;6(5):fcae331. doi: 10.1093/braincomms/fcae331. eCollection 2024. Brain Commun. 2024. PMID: 39403075 Free PMC article.
Multi-analyte proteomic analysis identifies blood-based neuroinflammation, cerebrovascular and synaptic biomarkers in preclinical Alzheimer's disease.
Zeng X, Lafferty TK, Sehrawat A, Chen Y, Ferreira PCL, Bellaver B, Povala G, Kamboh MI, Klunk WE, Cohen AD, Lopez OL, Ikonomovic MD, Pascoal TA, Ganguli M, Villemagne VL, Snitz BE, Karikari TK. Zeng X, et al. Among authors: ikonomovic md. Mol Neurodegener. 2024 Oct 10;19(1):68. doi: 10.1186/s13024-024-00753-5. Mol Neurodegener. 2024. PMID: 39385222 Free PMC article.
A streamlined, resource-efficient immunoprecipitation-mass spectrometry method for quantifying plasma amyloid-β biomarkers in Alzheimer's disease.
Karikari T, Chen Y, Zeng X, Olvera-Rojas M, Sehrawat A, Lafferty T, Pascoal T, Villemagne V, Solis-Urra P, Triviño-Ibañez E, Gómez-Rí M, Cohen A, Ikonomovic M, Esteban-Cornejo I, Erickson K, Lopez O, Yates N. Karikari T, et al. Among authors: ikonomovic m. Res Sq [Preprint]. 2024 Sep 2:rs.3.rs-4947448. doi: 10.21203/rs.3.rs-4947448/v1. Res Sq. 2024. PMID: 39281858 Free PMC article. Preprint.
Implementation and Assessment of Tau Thresholds in Non-Demented Individuals as Predictors of Cognitive Decline in Tau Imaging Studies.
Gogola A, Cohen AD, Snitz B, Minhas D, Tudorascu D, Ikonomovic MD, Shaaban CE, Doré V, Matan C, Bourgeat P, Mason NS, Leuzy A, Aizenstein H, Mathis CA, Lopez OL, Lopresti BJ, Villemagne VL; Alzheimer’s Disease Neuroimaging Initiative. Gogola A, et al. Among authors: ikonomovic md. J Alzheimers Dis. 2024;100(s1):S75-S92. doi: 10.3233/JAD-240543. J Alzheimers Dis. 2024. PMID: 39121123
Multi-analyte proteomic analysis identifies blood-based neuroinflammation, cerebrovascular and synaptic biomarkers in preclinical Alzheimer's disease.
Zeng X, Lafferty TK, Sehrawat A, Chen Y, Ferreira PCL, Bellaver B, Povala G, Kamboh MI, Klunk WE, Cohen AD, Lopez OL, Ikonomovic MD, Pascoal TA, Ganguli M, Villemagne VL, Snitz BE, Karikari TK. Zeng X, et al. Among authors: ikonomovic md. medRxiv [Preprint]. 2024 Jun 16:2024.06.15.24308975. doi: 10.1101/2024.06.15.24308975. medRxiv. 2024. Update in: Mol Neurodegener. 2024 Oct 10;19(1):68. doi: 10.1186/s13024-024-00753-5 PMID: 38947065 Free PMC article. Updated. Preprint.
A Neuropathology Case Report of a Woman with Down Syndrome who Remained Cognitively Stable.
Liou JJ, Lou J, Nakagiri J, Yong W, Hom CL, Doran EW, Totoiu M, Lott I, Mapstone M, Keator DB, Brickman AM, Wright S, Nelson B, Lai F, Xicota L, Dang LT, Li J, Santini T, Mettenburg JM, Ikonomovic MD, Kofler J, Ibrahim T, Head E; Alzheimer Biomarker Consortium - Down Syndrome. Liou JJ, et al. Among authors: ikonomovic md. medRxiv [Preprint]. 2024 Jun 3:2024.06.01.24308050. doi: 10.1101/2024.06.01.24308050. medRxiv. 2024. PMID: 38883742 Free PMC article. Preprint.
Correlating hippocampal and amygdala volumes with neuropathological burden in neurodegenerative diseases using 7T postmortem MRI.
Liou JJ, Li J, Berardinelli J, Jin H, Santini T, Noh J, Farhat N, Wu M, Aizenstein H, Mettenburg JM, Yong W, Head E, Ikonomovic M, Ibrahim T, Kofler J; Alzheimer’s Biomarker Consortium on Down syndrome study. Liou JJ, et al. Among authors: ikonomovic m. medRxiv [Preprint]. 2024 May 15:2024.05.15.24307354. doi: 10.1101/2024.05.15.24307354. medRxiv. 2024. PMID: 38798514 Free PMC article. Preprint.
166 results