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Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure.
Hahn S, Brüning T, Ness J, Czirr E, Baches S, Gijsen H, Korth C, Pietrzik CU, Bulic B, Weggen S. Hahn S, et al. Among authors: weggen s. J Neurochem. 2011 Feb;116(3):385-95. doi: 10.1111/j.1471-4159.2010.07118.x. Epub 2010 Dec 13. J Neurochem. 2011. PMID: 21091478 Free article.
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