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Reevaluating safety pharmacology respiratory studies within the ICH S7A core battery: A multi-company evaluation of preclinical utility and clinical translation.
Friedrichs GS, Abernathy MM, Ackley D, Clark M, DaSilva JK, Foley CM, Greiter-Wilke A, Henderson KA, Kremer JJ, Morimoto BH, Paglialunga S, Pugsley MK, Regan CP, Rossman EI, Segretti JA, Traebert M, Vargas HM, Wisialowski TA. Friedrichs GS, et al. Among authors: paglialunga s. Regul Toxicol Pharmacol. 2024 Nov;153:105706. doi: 10.1016/j.yrtph.2024.105706. Epub 2024 Sep 16. Regul Toxicol Pharmacol. 2024. PMID: 39293707
Prevalence of Baseline Cardiac Arrhythmias in Participants with Overweight or Obesity in Phase 1 Clinical Trials: Analysis of 24-Hour Holter Electrocardiogram Recordings.
Skovgaard D, Haahr PM, Lester R, Clark K, Paglialunga S, Finer N, Friedrichsen MH, Hjerpsted JB, Engelmann MDM. Skovgaard D, et al. Among authors: paglialunga s. J Clin Pharmacol. 2023 May;63(5):539-543. doi: 10.1002/jcph.2193. Epub 2023 Jan 20. J Clin Pharmacol. 2023. PMID: 36524539 Clinical Trial.
Evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of SM17 in healthy volunteers: results from pre-clinical models and a first-in-human, randomized, double blinded clinical trial.
Xu G, Paglialunga S, Qian X, Ding R, Webster K, van Haarst A, Engel C, Hui CW, Lam LH, Li W, Wu WC, Rasmussen S, Hunt A, Leung SO. Xu G, et al. Among authors: paglialunga s. Front Immunol. 2024 Dec 9;15:1495540. doi: 10.3389/fimmu.2024.1495540. eCollection 2024. Front Immunol. 2024. PMID: 39717777 Free PMC article. Clinical Trial.
Adipose Tissue Inflammation Is Directly Linked to Obesity-Induced Insulin Resistance, while Gut Dysbiosis and Mitochondrial Dysfunction Are Not Required.
Petrick HL, Foley KP, Zlitni S, Brunetta HS, Paglialunga S, Miotto PM, Politis-Barber V, O'Dwyer C, Philbrick DJ, Fullerton MD, Schertzer JD, Holloway GP. Petrick HL, et al. Among authors: paglialunga s. Function (Oxf). 2020 Aug 25;1(2):zqaa013. doi: 10.1093/function/zqaa013. eCollection 2020. Function (Oxf). 2020. PMID: 34278304 Free PMC article.
Long-term, high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration.
Politis-Barber V, Brunetta HS, Paglialunga S, Petrick HL, Holloway GP. Politis-Barber V, et al. Among authors: paglialunga s. Am J Physiol Endocrinol Metab. 2020 Aug 1;319(2):E376-E387. doi: 10.1152/ajpendo.00028.2020. Epub 2020 Jun 16. Am J Physiol Endocrinol Metab. 2020. PMID: 32543945 Free PMC article.
74 results