Abdel-Halim M - Search Results

1

Discovery of 1,3-disubstituted prop-2-en-1-one derivatives as inhibitors of neutrophilic inflammation via modulation of MAPK and Akt pathways.

Abdel-Halim M, El-Gamil DS, Hammam MA, El-Shazly M, Wang YH, Kung PH, Chen YC, Korinek M, Abadi AH, Engel M, Hwang TL. Abdel-Halim M, et al. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2402988. doi: 10.1080/14756366.2024.2402988. Epub 2024 Sep 19. J Enzyme Inhib Med Chem. 2024. PMID: 39297697 Free PMC article.

2

Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective.

Abadi AH, Gary BD, Tinsley HN, Piazza GA, Abdel-Halim M. Abadi AH, et al. Eur J Med Chem. 2010 Apr;45(4):1278-86. doi: 10.1016/j.ejmech.2009.10.046. Eur J Med Chem. 2010. PMID: 20206015 Free PMC article.

3

Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53.

Abdel-Halim M, Keeton AB, Gurpinar E, Gary BD, Vogel SM, Engel M, Piazza GA, Boeckler FM, Hartmann RW, Abadi AH. Abdel-Halim M, et al. Bioorg Med Chem. 2013 Dec 1;21(23):7343-56. doi: 10.1016/j.bmc.2013.09.055. Epub 2013 Oct 1. Bioorg Med Chem. 2013. PMID: 24139845

4

Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of protein kinase C-ζ.

Abdel-Halim M, Diesel B, Kiemer AK, Abadi AH, Hartmann RW, Engel M. Abdel-Halim M, et al. J Med Chem. 2014 Aug 14;57(15):6513-30. doi: 10.1021/jm500521n. Epub 2014 Jul 24. J Med Chem. 2014. PMID: 25058929

5

Synthesis and Optimization of New 3,6-Disubstitutedindole Derivatives and Their Evaluation as Anticancer Agents Targeting the MDM2/MDMx Complex.

Rezk MS, Abdel-Halim M, Keeton A, Franklin D, Bauer M, Boeckler FM, Engel M, Hartmann RW, Zhang Y, Piazza GA, Abadi AH. Rezk MS, et al. Chem Pharm Bull (Tokyo). 2016;64(1):34-41. doi: 10.1248/cpb.c15-00608. Chem Pharm Bull (Tokyo). 2016. PMID: 26726742 Free article.

6

Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhibitors.

Abadi AH, Lehmann J, Piazza GA, Abdel-Halim M, Ali MS. Abadi AH, et al. Int J Med Chem. 2011;2011:562421. doi: 10.1155/2011/562421. Epub 2011 Feb 23. Int J Med Chem. 2011. PMID: 27471602 Free PMC article.

7

Pharmacological inhibition of protein kinase C (PKC)ζ downregulates the expression of cytokines involved in the pathogenesis of chronic obstructive pulmonary disease (COPD).

Abdel-Halim M, Darwish SS, ElHady AK, Hoppstädter J, Abadi AH, Hartmann RW, Kiemer AK, Engel M. Abdel-Halim M, et al. Eur J Pharm Sci. 2016 Oct 10;93:405-9. doi: 10.1016/j.ejps.2016.08.016. Epub 2016 Aug 8. Eur J Pharm Sci. 2016. PMID: 27516147

8

Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins.

ElHady AK, Abdel-Halim M, Abadi AH, Engel M. ElHady AK, et al. J Med Chem. 2017 Jul 13;60(13):5377-5391. doi: 10.1021/acs.jmedchem.6b01915. Epub 2017 May 31. J Med Chem. 2017. PMID: 28561591

9

Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors.

El-Sharkawy LY, El-Sakhawy RA, Abdel-Halim M, Lee K, Piazza GA, Ducho C, Hartmann RW, Abadi AH. El-Sharkawy LY, et al. Arch Pharm (Weinheim). 2018 May;351(5):e1800018. doi: 10.1002/ardp.201800018. Epub 2018 Apr 14. Arch Pharm (Weinheim). 2018. PMID: 29656464

10

Design and synthesis of conformationally constraint Dyrk1A inhibitors by creating an intramolecular H-bond involving a benzothiazole core.

Salah M, Abdel-Halim M, Engel M. Salah M, et al. Medchemcomm. 2018 May 28;9(6):1045-1053. doi: 10.1039/c8md00142a. eCollection 2018 Jun 1. Medchemcomm. 2018. PMID: 30108993 Free PMC article.

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