Engel M - Search Results

1

Discovery of 1,3-disubstituted prop-2-en-1-one derivatives as inhibitors of neutrophilic inflammation via modulation of MAPK and Akt pathways.

Abdel-Halim M, El-Gamil DS, Hammam MA, El-Shazly M, Wang YH, Kung PH, Chen YC, Korinek M, Abadi AH, Engel M, Hwang TL. Abdel-Halim M, et al. Among authors: engel m. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2402988. doi: 10.1080/14756366.2024.2402988. Epub 2024 Sep 19. J Enzyme Inhib Med Chem. 2024. PMID: 39297697 Free PMC article.

2

3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds.

Stroba A, Schaeffer F, Hindie V, Lopez-Garcia L, Adrian I, Fröhner W, Hartmann RW, Biondi RM, Engel M. Stroba A, et al. Among authors: engel m. J Med Chem. 2009 Aug 13;52(15):4683-93. doi: 10.1021/jm9001499. J Med Chem. 2009. PMID: 19606904

3

4-benzimidazolyl-3-phenylbutanoic acids as novel PIF-pocket-targeting allosteric inhibitors of protein kinase PKCζ.

Fröhner W, Lopez-Garcia LA, Neimanis S, Weber N, Navratil J, Maurer F, Stroba A, Zhang H, Biondi RM, Engel M. Fröhner W, et al. Among authors: engel m. J Med Chem. 2011 Oct 13;54(19):6714-23. doi: 10.1021/jm2005892. Epub 2011 Sep 14. J Med Chem. 2011. PMID: 21863889

4

2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept.

Wilhelm A, Lopez-Garcia LA, Busschots K, Fröhner W, Maurer F, Boettcher S, Zhang H, Schulze JO, Biondi RM, Engel M. Wilhelm A, et al. Among authors: engel m. J Med Chem. 2012 Nov 26;55(22):9817-30. doi: 10.1021/jm3010477. Epub 2012 Nov 12. J Med Chem. 2012. PMID: 23106316

5

Design of novel β-carboline derivatives with pendant 5-bromothienyl and their evaluation as phosphodiesterase-5 inhibitors.

El-Gamil DS, Ahmed NS, Gary BD, Piazza GA, Engel M, Hartmann RW, Abadi AH. El-Gamil DS, et al. Among authors: engel m. Arch Pharm (Weinheim). 2013 Jan;346(1):23-33. doi: 10.1002/ardp.201200334. Arch Pharm (Weinheim). 2013. PMID: 23307609 Free PMC article.

6

6-Aryl and heterocycle quinazoline derivatives as potent EGFR inhibitors with improved activity toward gefitinib-sensitive and -resistant tumor cell lines.

Hamed MM, Abou El Ella DA, Keeton AB, Piazza GA, Abadi AH, Hartmann RW, Engel M. Hamed MM, et al. Among authors: engel m. ChemMedChem. 2013 Sep;8(9):1495-504. doi: 10.1002/cmdc.201300147. Epub 2013 Jul 11. ChemMedChem. 2013. PMID: 23847159

7

Highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases.

Pinto-Bazurco Mendieta MA, Hu Q, Engel M, Hartmann RW. Pinto-Bazurco Mendieta MA, et al. Among authors: engel m. J Med Chem. 2013 Aug 8;56(15):6101-7. doi: 10.1021/jm400484p. Epub 2013 Jul 29. J Med Chem. 2013. PMID: 23859149

8

Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53.

Abdel-Halim M, Keeton AB, Gurpinar E, Gary BD, Vogel SM, Engel M, Piazza GA, Boeckler FM, Hartmann RW, Abadi AH. Abdel-Halim M, et al. Among authors: engel m. Bioorg Med Chem. 2013 Dec 1;21(23):7343-56. doi: 10.1016/j.bmc.2013.09.055. Epub 2013 Oct 1. Bioorg Med Chem. 2013. PMID: 24139845

9

Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of protein kinase C-ζ.

Abdel-Halim M, Diesel B, Kiemer AK, Abadi AH, Hartmann RW, Engel M. Abdel-Halim M, et al. Among authors: engel m. J Med Chem. 2014 Aug 14;57(15):6513-30. doi: 10.1021/jm500521n. Epub 2014 Jul 24. J Med Chem. 2014. PMID: 25058929

10

Synthesis and Optimization of New 3,6-Disubstitutedindole Derivatives and Their Evaluation as Anticancer Agents Targeting the MDM2/MDMx Complex.

Rezk MS, Abdel-Halim M, Keeton A, Franklin D, Bauer M, Boeckler FM, Engel M, Hartmann RW, Zhang Y, Piazza GA, Abadi AH. Rezk MS, et al. Among authors: engel m. Chem Pharm Bull (Tokyo). 2016;64(1):34-41. doi: 10.1248/cpb.c15-00608. Chem Pharm Bull (Tokyo). 2016. PMID: 26726742 Free article.

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