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Page 1
Disrupted uromodulin trafficking is rescued by targeting TMED cargo receptors.
Bazua-Valenti S, Brown MR, Zavras J, Riedl Khursigara M, Grinkevich E, Sidhom EH, Keller KH, Racette M, Dvela-Levitt M, Quintanova C, Demirci H, Sewerin S, Goss AC, Lin J, Yoo H, Vaca Jacome AS, Papanastasiou M, Udeshi N, Carr SA, Himmerkus N, Bleich M, Mutig K, Bachmann S, Halbritter J, Kmoch S, Živná M, Kidd K, Bleyer AJ, Weins A, Alper SL, Shaw JL, Kost-Alimova M, Pablo JLB, Greka A. Bazua-Valenti S, et al. J Clin Invest. 2024 Dec 16;134(24):e180347. doi: 10.1172/JCI180347. J Clin Invest. 2024. PMID: 39680459 Free PMC article.
Molecular basis of TMED9 oligomerization and entrapment of misfolded protein cargo in the early secretory pathway.
Xiao L, Pi X, Goss AC, El-Baba T, Ehrmann JF, Grinkevich E, Bazua-Valenti S, Padovano V, Alper SL, Carey D, Udeshi ND, Carr SA, Pablo JL, Robinson CV, Greka A, Wu H. Xiao L, et al. Among authors: bazua valenti s. Sci Adv. 2024 Sep 20;10(38):eadp2221. doi: 10.1126/sciadv.adp2221. Epub 2024 Sep 20. Sci Adv. 2024. PMID: 39303030 Free PMC article.
Glucose/Fructose Delivery to the Distal Nephron Activates the Sodium-Chloride Cotransporter via the Calcium-Sensing Receptor.
Bahena-Lopez JP, Rojas-Vega L, Chávez-Canales M, Bazua-Valenti S, Bautista-Pérez R, Lee JH, Madero M, Vazquez-Manjarrez N, Alquisiras-Burgos I, Hernandez-Cruz A, Castañeda-Bueno M, Ellison DH, Gamba G. Bahena-Lopez JP, et al. Among authors: bazua valenti s. J Am Soc Nephrol. 2023 Jan 1;34(1):55-72. doi: 10.1681/ASN.2021121544. Epub 2022 Oct 26. J Am Soc Nephrol. 2023. PMID: 36288902 Free PMC article.
High-resolution Slide-seqV2 spatial transcriptomics enables discovery of disease-specific cell neighborhoods and pathways.
Marshall JL, Noel T, Wang QS, Chen H, Murray E, Subramanian A, Vernon KA, Bazua-Valenti S, Liguori K, Keller K, Stickels RR, McBean B, Heneghan RM, Weins A, Macosko EZ, Chen F, Greka A. Marshall JL, et al. Among authors: bazua valenti s. iScience. 2022 Mar 16;25(4):104097. doi: 10.1016/j.isci.2022.104097. eCollection 2022 Apr 15. iScience. 2022. PMID: 35372810 Free PMC article.
Factors Associated with Development of Acute Kidney Injury After Liver Transplantation.
Catalán R, Jiménez-Ceja JV, Rincón-Pedrero R, Olivas-Martínez A, Martínez-Rueda AJ, Bazúa-Valenti S, Carrillo-Pérez DL, Grajeda-Medina LI, García-Juárez I, Vilatobá M, Ortega-Trejo JA, Pérez-Villalva R, Bobadilla NA, Moreno E, Gamba G. Catalán R, et al. Among authors: bazua valenti s. Rev Invest Clin. 2022 Mar 15;74(2):090-096. doi: 10.24875/RIC.21000496. Rev Invest Clin. 2022. PMID: 35038259 Free article.
A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury.
Kost-Alimova M, Sidhom EH, Satyam A, Chamberlain BT, Dvela-Levitt M, Melanson M, Alper SL, Santos J, Gutierrez J, Subramanian A, Byrne PJ, Grinkevich E, Reyes-Bricio E, Kim C, Clark AR, Watts AJB, Thompson R, Marshall J, Pablo JL, Coraor J, Roignot J, Vernon KA, Keller K, Campbell A, Emani M, Racette M, Bazua-Valenti S, Padovano V, Weins A, McAdoo SP, Tam FWK, Ronco L, Wagner F, Tsokos GC, Shaw JL, Greka A. Kost-Alimova M, et al. Among authors: bazua valenti s. Cell Rep Med. 2020 Oct 29;1(8):100137. doi: 10.1016/j.xcrm.2020.100137. eCollection 2020 Nov 17. Cell Rep Med. 2020. PMID: 33294858 Free PMC article.
A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic.
Alimova M, Sidhom EH, Satyam A, Dvela-Levitt M, Melanson M, Chamberlain BT, Alper SL, Santos J, Gutierrez J, Subramanian A, Grinkevich E, Bricio ER, Kim C, Clark A, Watts A, Thompson R, Marshall J, Pablo JL, Coraor J, Roignot J, Vernon KA, Keller K, Campbell A, Emani M, Racette M, Bazua-Valenti S, Padovano V, Weins A, McAdoo SP, Tam FWK, Ronco L, Wagner F, Tsokos GC, Shaw JL, Greka A. Alimova M, et al. Among authors: bazua valenti s. bioRxiv [Preprint]. 2020 Jun 30:2020.06.30.180380. doi: 10.1101/2020.06.30.180380. bioRxiv. 2020. Update in: Cell Rep Med. 2020 Oct 29;1(8):100137. doi: 10.1016/j.xcrm.2020.100137 PMID: 32637960 Free PMC article. Updated. Preprint.
C-terminally truncated, kidney-specific variants of the WNK4 kinase lack several sites that regulate its activity.
Murillo-de-Ozores AR, Rodríguez-Gama A, Bazúa-Valenti S, Leyva-Ríos K, Vázquez N, Pacheco-Álvarez D, De La Rosa-Velázquez IA, Wengi A, Stone KL, Zhang J, Loffing J, Lifton RP, Yang CL, Ellison DH, Gamba G, Castañeda-Bueno M. Murillo-de-Ozores AR, et al. Among authors: bazua valenti s. J Biol Chem. 2018 Aug 3;293(31):12209-12221. doi: 10.1074/jbc.RA118.003037. Epub 2018 Jun 19. J Biol Chem. 2018. PMID: 29921588 Free PMC article.
The Calcium-Sensing Receptor Increases Activity of the Renal NCC through the WNK4-SPAK Pathway.
Bazúa-Valenti S, Rojas-Vega L, Castañeda-Bueno M, Barrera-Chimal J, Bautista R, Cervantes-Pérez LG, Vázquez N, Plata C, Murillo-de-Ozores AR, González-Mariscal L, Ellison DH, Riccardi D, Bobadilla NA, Gamba G. Bazúa-Valenti S, et al. J Am Soc Nephrol. 2018 Jul;29(7):1838-1848. doi: 10.1681/ASN.2017111155. Epub 2018 May 30. J Am Soc Nephrol. 2018. PMID: 29848507 Free PMC article.
17 results