Temple KJ - Search Results

1

Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M₄ Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM).

Engers JL, Baker LA, Chang S, Luscombe VB, Rodriguez AL, Niswender CM, Cho HP, Bubser M, Gray AT, Jones CK, Peng W, Rook JM, Bridges TM, Boutaud O, Conn PJ, Engers DW, Lindsley CW, Temple KJ. Engers JL, et al. Among authors: temple kj. ACS Chem Neurosci. 2024 Sep 24;15(20):3744-54. doi: 10.1021/acschemneuro.4c00465. Online ahead of print. ACS Chem Neurosci. 2024. PMID: 39316465 Free PMC article.

2

Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists.

Witt JO, McCollum AL, Hurtado MA, Huseman ED, Jeffries DE, Temple KJ, Plumley HC, Blobaum AL, Lindsley CW, Hopkins CR. Witt JO, et al. Among authors: temple kj. Bioorg Med Chem Lett. 2016 May 15;26(10):2481-2488. doi: 10.1016/j.bmcl.2016.03.102. Epub 2016 Mar 30. Bioorg Med Chem Lett. 2016. PMID: 27080176 Free PMC article.

3

Development of a Series of (1-Benzyl-3-(6-methoxypyrimidin-3-yl)-5-(trifluoromethoxy)-1H-indol-2-yl)methanols as Selective Protease Activated Receptor 4 (PAR4) Antagonists with in Vivo Utility and Activity Against γ-Thrombin.

Temple KJ, Duvernay MT, Young SE, Wen W, Wu W, Maeng JG, Blobaum AL, Stauffer SR, Hamm HE, Lindsley CW. Temple KJ, et al. J Med Chem. 2016 Aug 25;59(16):7690-5. doi: 10.1021/acs.jmedchem.6b00928. Epub 2016 Aug 8. J Med Chem. 2016. PMID: 27482618 Free PMC article.

4

Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazoles.

Temple KJ, Duvernay MT, Maeng JG, Blobaum AL, Stauffer SR, Hamm HE, Lindsley CW. Temple KJ, et al. Bioorg Med Chem Lett. 2016 Nov 15;26(22):5481-5486. doi: 10.1016/j.bmcl.2016.10.020. Epub 2016 Oct 11. Bioorg Med Chem Lett. 2016. PMID: 27777004 Free PMC article.

5

Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation in Human Platelets.

Duvernay MT, Temple KJ, Maeng JG, Blobaum AL, Stauffer SR, Lindsley CW, Hamm HE. Duvernay MT, et al. Among authors: temple kj. Mol Pharmacol. 2017 Jan;91(1):39-47. doi: 10.1124/mol.116.106666. Epub 2016 Oct 26. Mol Pharmacol. 2017. PMID: 27784794 Free PMC article.

6

Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis.

Borza CM, Su Y, Tran TL, Yu L, Steyns N, Temple KJ, Skwark MJ, Meiler J, Lindsley CW, Hicks BR, Leitinger B, Zent R, Pozzi A. Borza CM, et al. Among authors: temple kj. Matrix Biol. 2017 Jan;57-58:258-271. doi: 10.1016/j.matbio.2016.11.009. Epub 2016 Dec 1. Matrix Biol. 2017. PMID: 27915093 Free PMC article.

7

Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (D₄R) antagonists.

Jeffries DE, Witt JO, McCollum AL, Temple KJ, Hurtado MA, Harp JM, Blobaum AL, Lindsley CW, Hopkins CR. Jeffries DE, et al. Among authors: temple kj. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5757-5764. doi: 10.1016/j.bmcl.2016.10.049. Epub 2016 Oct 17. Bioorg Med Chem Lett. 2016. PMID: 28327307

8

Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions.

Rigg RA, Healy LD, Chu TT, Ngo ATP, Mitrugno A, Zilberman-Rudenko J, Aslan JE, Hinds MT, Vecchiarelli LD, Morgan TK, Gruber A, Temple KJ, Lindsley CW, Duvernay MT, Hamm HE, McCarty OJT. Rigg RA, et al. Among authors: temple kj. Platelets. 2019;30(1):126-135. doi: 10.1080/09537104.2017.1406076. Epub 2018 Dec 18. Platelets. 2019. PMID: 30560697 Free PMC article.

9

M₁ Muscarinic Receptors Modulate Fear-Related Inputs to the Prefrontal Cortex: Implications for Novel Treatments of Posttraumatic Stress Disorder.

Maksymetz J, Joffe ME, Moran SP, Stansley BJ, Li B, Temple K, Engers DW, Lawrence JJ, Lindsley CW, Conn PJ. Maksymetz J, et al. Biol Psychiatry. 2019 Jun 15;85(12):989-1000. doi: 10.1016/j.biopsych.2019.02.020. Epub 2019 Mar 7. Biol Psychiatry. 2019. PMID: 31003787 Free PMC article.

10

Discovery of a novel 3,4-dimethylcinnoline carboxamide M₄ positive allosteric modulator (PAM) chemotype via scaffold hopping.

Temple KJ, Engers JL, Long MF, Gregro AR, Watson KJ, Chang S, Jenkins MT, Luscombe VB, Rodriguez AL, Niswender CM, Bridges TM, Conn PJ, Engers DW, Lindsley CW. Temple KJ, et al. Bioorg Med Chem Lett. 2019 Nov 1;29(21):126678. doi: 10.1016/j.bmcl.2019.126678. Epub 2019 Sep 10. Bioorg Med Chem Lett. 2019. PMID: 31537424

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