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Increased neuronal expression of the early endosomal adaptor APPL1 leads to endosomal and synaptic dysfunction with cholinergic neurodegeneration.
Jiang Y, Sachdeva K, Goulbourne CN, Berg MJ, Peddy J, Stavrides PH, Pensalfini A, Pawlik M, Whyte L, Balapal BS, Shivakumar S, Bleiwas C, Smiley JF, Mathews PM, Nixon RA. Jiang Y, et al. Among authors: goulbourne cn. bioRxiv [Preprint]. 2024 Sep 20:2024.09.19.613736. doi: 10.1101/2024.09.19.613736. bioRxiv. 2024. PMID: 39345644 Free PMC article. Preprint.
Cystatin C loaded in brain-derived extracellular vesicles rescues synapses after ischemic insult in vitro and in vivo.
Gui Y, Kim Y, Brenna S, Wilmes M, Zaghen G, Goulbourne CN, Kuchenbecker-Pöls L, Siebels B, Voß H, Gocke A, Schlüter H, Schweizer M, Altmeppen HC, Magnus T, Levy E, Puig B. Gui Y, et al. Among authors: goulbourne cn. Cell Mol Life Sci. 2024 May 20;81(1):224. doi: 10.1007/s00018-024-05266-4. Cell Mol Life Sci. 2024. PMID: 38769196 Free PMC article.
Cocaine perturbs mitovesicle biology in the brain.
D'Acunzo P, Ungania JM, Kim Y, Barreto BR, DeRosa S, Pawlik M, Canals-Baker S, Erdjument-Bromage H, Hashim A, Goulbourne CN, Neubert TA, Saito M, Sershen H, Levy E. D'Acunzo P, et al. Among authors: goulbourne cn. J Extracell Vesicles. 2023 Jan;12(1):e12301. doi: 10.1002/jev2.12301. J Extracell Vesicles. 2023. PMID: 36691887 Free PMC article.
Autophagy is a novel pathway for neurofilament protein degradation in vivo.
Rao MV, Darji S, Stavrides PH, Goulbourne CN, Kumar A, Yang DS, Yoo L, Peddy J, Lee JH, Yuan A, Nixon RA. Rao MV, et al. Among authors: goulbourne cn. Autophagy. 2023 Apr;19(4):1277-1292. doi: 10.1080/15548627.2022.2124500. Epub 2022 Sep 21. Autophagy. 2023. PMID: 36131358 Free PMC article.
Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency.
González BJ, Zhao H, Niu J, Williams DJ, Lee J, Goulbourne CN, Xing Y, Wang Y, Oberholzer J, Blumenkrantz MH, Chen X, LeDuc CA, Chung WK, Colecraft HM, Gromada J, Shen Y, Goland RS, Leibel RL, Egli D. González BJ, et al. Among authors: goulbourne cn. Commun Biol. 2022 Aug 2;5(1):779. doi: 10.1038/s42003-022-03696-z. Commun Biol. 2022. PMID: 35918471 Free PMC article.
40 results