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Page 1
Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype.
Leppä AM, Grimes K, Jeong H, Huang FY, Andrades A, Waclawiczek A, Boch T, Jauch A, Renders S, Stelmach P, Müller-Tidow C, Karpova D, Sohn M, Grünschläger F, Hasenfeld P, Benito Garagorri E, Thiel V, Dolnik A, Rodriguez-Martin B, Bullinger L, Mrózek K, Eisfeld AK, Krämer A, Sanders AD, Korbel JO, Trumpp A. Leppä AM, et al. Among authors: dolnik a. Nat Genet. 2024 Dec;56(12):2790-2803. doi: 10.1038/s41588-024-01999-x. Epub 2024 Nov 25. Nat Genet. 2024. PMID: 39587361 Free PMC article.
A high proportion of germline variants in pediatric chronic myeloid leukemia.
Krumbholz M, Dolnik A, Sträng E, Ghete T, Skambraks S, Hutter S, Simonis A, Stegelmann F, Suttorp M, Horn AHC, Sticht H, Haferlach T, Bullinger L, Metzler M. Krumbholz M, et al. Among authors: dolnik a. Mol Cancer. 2024 Sep 26;23(1):206. doi: 10.1186/s12943-024-02109-5. Mol Cancer. 2024. PMID: 39327604 Free PMC article.
Genomic characterization of AML with aberrations of chromosome 7: a multinational cohort of 519 patients.
Halik A, Tilgner M, Silva P, Estrada N, Altwasser R, Jahn E, Heuser M, Hou HA, Pratcorona M, Hills RK, Metzeler KH, Fenwarth L, Dolnik A, Terre C, Kopp K, Blau O, Szyska M, Christen F, Krönke J, Vasseur L, Löwenberg B, Esteve J, Valk PJM, Duchmann M, Chou WC, Linch DC, Döhner H, Gale RE, Döhner K, Bullinger L, Yoshida K, Damm F. Halik A, et al. Among authors: dolnik a. J Hematol Oncol. 2024 Aug 19;17(1):70. doi: 10.1186/s13045-024-01590-1. J Hematol Oncol. 2024. PMID: 39160538 Free PMC article.
Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13).
Weichenhan D, Riedel A, Sollier E, Toprak UH, Hey J, Breuer K, Wierzbinska JA, Touzart A, Lutsik P, Bähr M, Östlund A, Nilsson T, Jacobsson S, Edler M, Waraky A, Behrens YL, Göhring G, Schlegelberger B, Steinek C, Harz H, Leonhardt H, Dolnik A, Reinhardt D, Bullinger L, Palmqvist L, Lipka DB, Plass C. Weichenhan D, et al. Among authors: dolnik a. Blood Adv. 2024 Oct 8;8(19):5100-5111. doi: 10.1182/bloodadvances.2023012161. Blood Adv. 2024. PMID: 39121370 Free PMC article.
The proteogenomic landscape of multiple myeloma reveals insights into disease biology and therapeutic opportunities.
Ramberger E, Sapozhnikova V, Ng YLD, Dolnik A, Ziehm M, Popp O, Sträng E, Kull M, Grünschläger F, Krüger J, Benary M, Müller S, Gao X, Murgai A, Haji M, Schmidt A, Lutz R, Nogai A, Braune J, Laue D, Langer C, Khandanpour C, Bassermann F, Döhner H, Engelhardt M, Straka C, Hundemer M, Beule D, Haas S, Keller U, Einsele H, Bullinger L, Knop S, Mertins P, Krönke J. Ramberger E, et al. Among authors: dolnik a. Nat Cancer. 2024 Aug;5(8):1267-1284. doi: 10.1038/s43018-024-00784-3. Epub 2024 Jun 28. Nat Cancer. 2024. PMID: 38942927 Free PMC article.
AML with complex karyotype: extreme genomic complexity revealed by combined long-read sequencing and Hi-C technology.
Klever MK, Sträng E, Hetzel S, Jungnitsch J, Dolnik A, Schöpflin R, Schrezenmeier JF, Schick F, Blau O, Westermann J, Rücker FG, Xia Z, Döhner K, Schrezenmeier H, Spielmann M, Meissner A, Melo US, Mundlos S, Bullinger L. Klever MK, et al. Among authors: dolnik a. Blood Adv. 2023 Nov 14;7(21):6520-6531. doi: 10.1182/bloodadvances.2023010887. Blood Adv. 2023. PMID: 37582288 Free PMC article.
Retained functional normal and preleukemic HSCs at diagnosis are associated with good prognosis in DNMT3AmutNPM1mut AMLs.
Donato E, Correia N, Andresen C, Karpova D, Würth R, Klein C, Sohn M, Przybylla A, Zeisberger P, Rothfelder K, Salih H, Bonig H, Stasik S, Röllig C, Dolnik A, Bullinger L, Buchholz F, Thiede C, Hübschmann D, Trumpp A. Donato E, et al. Among authors: dolnik a. Blood Adv. 2023 Mar 28;7(6):1011-1018. doi: 10.1182/bloodadvances.2022008497. Blood Adv. 2023. PMID: 36453648 Free PMC article.
Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.
Ng YLD, Ramberger E, Bohl SR, Dolnik A, Steinebach C, Conrad T, Müller S, Popp O, Kull M, Haji M, Gütschow M, Döhner H, Walther W, Keller U, Bullinger L, Mertins P, Krönke J. Ng YLD, et al. Among authors: dolnik a. Nat Commun. 2022 Feb 23;13(1):1009. doi: 10.1038/s41467-022-28515-1. Nat Commun. 2022. PMID: 35197447 Free PMC article.
PLCG1 is required for AML1-ETO leukemia stem cell self-renewal.
Schnoeder TM, Schwarzer A, Jayavelu AK, Hsu CJ, Kirkpatrick J, Döhner K, Perner F, Eifert T, Huber N, Arreba-Tutusaus P, Dolnik A, Assi SA, Nafria M, Jiang L, Dai YT, Chen Z, Chen SJ, Kellaway SG, Ptasinska A, Ng ES, Stanley EG, Elefanty AG, Buschbeck M, Bierhoff H, Brodt S, Matziolis G, Fischer KD, Hochhaus A, Chen CW, Heidenreich O, Mann M, Lane SW, Bullinger L, Ori A, von Eyss B, Bonifer C, Heidel FH. Schnoeder TM, et al. Among authors: dolnik a. Blood. 2022 Feb 17;139(7):1080-1097. doi: 10.1182/blood.2021012778. Blood. 2022. PMID: 34695195 Free PMC article.
47 results