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RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site.
Haza KZ, Martin HL, Rao A, Turner AL, Saunders SE, Petersen B, Tiede C, Tipping K, Tang AA, Ajayi M, Taylor T, Harvey M, Fishwick KM, Adams TL, Gaule TG, Trinh CH, Johnson M, Breeze AL, Edwards TA, McPherson MJ, Tomlinson DC. Haza KZ, et al. Nat Commun. 2021 Jun 30;12(1):4045. doi: 10.1038/s41467-021-24316-0. Nat Commun. 2021. PMID: 34193876 Free PMC article.
High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology.
Muhammad A, Calandranis ME, Li B, Yang T, Blackwell DJ, Harvey ML, Smith JE, Chew AE, Capra JA, Matreyek KA, Fowler DM, Roden DM, Glazer AM. Muhammad A, et al. Among authors: harvey ml. bioRxiv [Preprint]. 2023 Apr 29:2023.04.28.538612. doi: 10.1101/2023.04.28.538612. bioRxiv. 2023. Update in: Genome Med. 2024 May 30;16(1):73. doi: 10.1186/s13073-024-01340-5 PMID: 37162834 Free PMC article. Updated. Preprint.
Enhanced Fitness of a Helicobacter pylori babA Mutant in a Murine Model.
Harvey ML, Lin AS, Sun L, Koyama T, Shuman JHB, Loh JT, Algood HMS, Scholz MB, McClain MS, Cover TL. Harvey ML, et al. Infect Immun. 2021 Sep 16;89(10):e0072520. doi: 10.1128/IAI.00725-20. Epub 2021 Jul 12. Infect Immun. 2021. PMID: 34310886 Free PMC article.
39 results