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Anti-metabolite chemotherapy increases LAG-3 expressing tumor-infiltrating lymphocytes which can be targeted by combination immune checkpoint blockade.
Principe N, Phung AL, Stevens KLP, Elaskalani O, Wylie B, Tilsed CM, Sheikh F, Orozco Morales ML, Kidman J, Marcq E, Fisher SA, Nowak AK, McDonnell AM, Lesterhuis WJ, Chee J. Principe N, et al. Among authors: wylie b. J Immunother Cancer. 2024 Sep 28;12(9):e008568. doi: 10.1136/jitc-2023-008568. J Immunother Cancer. 2024. PMID: 39343508 Free PMC article.
Local therapy with combination TLR agonists stimulates systemic anti-tumor immunity and sensitizes tumors to immune checkpoint blockade.
Rwandamuriye FX, Wang T, Zhang H, Elaskalani O, Kuster J, Ye X, Vitali B, Schreurs J, Orozco Morales ML, Norret M, Evans CW, Zemek RM, Iyer KS, Lesterhuis WJ, Wylie B. Rwandamuriye FX, et al. Among authors: wylie b. Oncoimmunology. 2024 Aug 22;13(1):2395067. doi: 10.1080/2162402X.2024.2395067. eCollection 2024. Oncoimmunology. 2024. PMID: 39188754 Free PMC article.
Neoadjuvant anti-tumor vaccination prior to surgery enhances survival.
Fisher SA, Cleaver A, Lakhiani DD, Khong A, Connor T, Wylie B, Lesterhuis WJ, Robinson BW, Lake RA. Fisher SA, et al. Among authors: wylie b. J Transl Med. 2014 Sep 4;12:245. doi: 10.1186/s12967-014-0245-7. J Transl Med. 2014. PMID: 25186961 Free PMC article.
Diverse Anti-Tumor Immune Potential Driven by Individual IFNα Subtypes.
Buzzai AC, Wagner T, Audsley KM, Newnes HV, Barrett LW, Barnes S, Wylie BC, Stone S, McDonnell A, Fear VS, Foley B, Waithman J. Buzzai AC, et al. Among authors: wylie bc. Front Immunol. 2020 Apr 3;11:542. doi: 10.3389/fimmu.2020.00542. eCollection 2020. Front Immunol. 2020. PMID: 32308653 Free PMC article.
IFNβ Is a Potent Adjuvant for Cancer Vaccination Strategies.
Audsley KM, Wagner T, Ta C, Newnes HV, Buzzai AC, Barnes SA, Wylie B, Armitage J, Kaisho T, Bosco A, McDonnell A, Cruickshank M, Fear VS, Foley B, Waithman J. Audsley KM, et al. Among authors: wylie b. Front Immunol. 2021 Sep 6;12:735133. doi: 10.3389/fimmu.2021.735133. eCollection 2021. Front Immunol. 2021. PMID: 34552594 Free PMC article.
316 results